1. Pharmacological action Cimetidine
2. Analogs Cimetidine
3. Indications drug
4. Contraindications to the use of Cimetidine
5. cimetidine: instructions for use
6. drug interactions
7. Side effects Cimetidine
8. storage conditions
cimetidine is an effective drug that belongs to the group of blockershistamine H2-receptor.This medication inhibits the production of hydrochloric acid.The main indications for the use of Cimetidine include: heartburn, canker of the stomach and duodenum in the acute stage, reflux esophagitis, and systemic mastocytosis.
above drug is effective blocker of histamine H2-receptor that inhibits the production of hydrochloric acid, stimulated by acetylcholine, histamine, gastrin and food.Reducing the concentration of hydrochloric acid reduces drug action of pepsin and pH increases.According
instruction starts cimetidine gastric mucosal protective mechanism layer significantly reduces the level o
After oral therapeutic effect Cimetidine occurs within 60 minutes and continues to operate for 4-5 hours.Absorbed the tool from the gastrointestinal tract is pretty good.Metabolism occurs usually when the "first pass".With regard to the bioavailability of the medicament, it is 60-70%.The maximum concentration of the active substance in blood plasma (at reception on an empty stomach) is achieved in one hour, while the second peak may be observed after three hours.The level of drug binding protein - 20%.
Cimetidine-life occurs within two hours.If the kidney function, this process can drag on a bit.Displays the drug is excreted in the urine in unchanged form.
Currently, the most common are analogues Cimetidine following medications: Gistodil, Belomet, Simesan, Primamet Lannaher and cimetidine.
Regulations cimetidine recommends the use of this tool in the following pathological conditions:
addition, cimetidine may also be used as an auxiliary component of the integrated treatment of urticaria, rheumatoid arthritis and pancreatic insufficiency enzyme.
This drug should not be applied to persons with hypersensitivity to the active substance or additional components of the drug.
cimetidine according to the instructions should be administered only doctor.Dosage is established based on the patient's general condition.A single dose of the drug in tablet form for adults is 100-800 mg.Regarding
Cimetidine intravenous administration, the single dose in this case is equal to 200 mg, while an intravenous infusion - 400 mg.
According to the instructions, the maximum daily dosage of the above medications should not exceed 2 g (regardless of the method of administration).The maximum tolerable daily intake for children under one year is 20 milligrams per kilogram of body weight, for children over one year - 25-30 milligrams per kilogram of body weight.
Cimetidine Complex application with antacids containing magnesium hydroxide and aluminum hydroxide, reduces the absorption of the former.Simultaneous administration of drugs with hypoglycemic agents sometimes provokes hypoglycemia.Cimetidine
combination with triazolam, clorazepate, alprazolam, chlordiazepoxide, nitrazepama, klobazamom, flurazepam and diazepam benzodiazepine level increases in plasma and enhances sedation.
combination with benzylpenicillin Cimetidine increases the bioavailability of the latter.
simultaneous use of the drug atenolol sometimes cause bradycardia.
aforementioned agent enhances the effect of verapamil, vecuronium chloride and gallopamil.
combination with indomethacin reduces its level in the blood plasma.
Cimetidine combination with ketoconazole and itraconazole reduces their absorption in the digestive tract.
cimetidine increases the concentration of lidocaine in the blood reduces its clearance, and also leads to increased side effects of the anesthetic.
According to the instructions, cimetidine and analogues of the drug can trigger the occurrence of the following adverse reactions:
cimetidine and analogues medications should be stored in protected from light and the reach of children at room temperature.
Product description posted on this page is a supplement and a simplified version of the official version of the annotations to the drug.The information is provided for informational purposes only and is not a guide to self-medication.Before using the product you should consult with a specialist and to get acquainted with the instructions approved by the manufacturer.
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