Temodal - instruction , application reviews


1. composition and the form of

2. Pharmacological action Temodal

3. Therapeutic indications Temodal

4. Use of Temodal for

instructions5. Contraindications Temodal

6. Side effects of the drug Temodal

7. Cautions

Temodal - anticancer drug for the treatment of cancer.It prevents the development of tumors and restores the body during chemotherapy.International name of the drug - Temozolomide.

Structure and Composition

Temodal produced in the form of capsules, each containing 5, 20, 100 or 250 mg of active substance - temozolomide.The role of accessory components are: silicon dioxide, lactose, starch, stearic acid and tartaric acid.shell composition: titanium dioxide, indigo carmine, gelatin, sodium alaurilsulfat, yellow iron oxide.The preparation is realized in glass vials containing 5 or 20 capsules.

pharmacological action of Temodal Temodal shows

expressed alkylating action, thanks to which is carried out braking process of cell division and the

development of a tumor.

good reviews about Temodal and also based on the fact that the drug is rapidly absorbed by the body and provide a positive therapeutic effect already within 1 hour after the first application.

Active drug substance does not lead to serious violations of the functioning of the liver and kidneys.


Temodal Temodal is used for the treatment of the following cancers:

  • metastatic malignant melanoma;
  • malignant glioma (in the case of recurrence or progression after standard therapy);
  • first revealed glioblastoma multiforme (a part of a combined treatment together with radiotherapy and further adjuvant monotherapy).

frequent positive comments about Temodal as an effective medication for the prevention and elimination of complications of progressive processes of cancer.

Application Temodal for

instructions According to the instructions for Temodal, adult patients and children over three years of taking the drug at 100 mg twice daily.The capsules should be taken on an empty stomach at least 1 hour before meals.They swallow whole, washed down with a glass of water.The course of treatment without chemotherapy lasts 28 days.

If Temodal is used on the background radiation therapy, drug therapy scheme as follows: 150 mg once a day during the treatment cycle I and 200 mg in a single dose per day - during the II cycle of treatment.According to the instructions

Temodal if the patient relapses glioblastoma multiforme type is taken once daily 75 mg for 42 days (compared to radiotherapy).

exact daily dosage of medication determined by the physician based on the patient's diagnostic indications.In some cases, drug treatment Temodal divided into six periods with interruptions in the reception or decrease dosage therebetween.Typically, the total course of medication therapy lasts for 2 years.

Contraindications Temodal

The instructions to Temodal marked by a number of contraindications to treatment preparation:

  • serious hereditary diseases (metabolic disorders, lactase deficiency, and others.);
  • renal failure;
  • hemorrhagic cystitis;
  • pregnancy and lactation period;
  • hypersensitivity to constituents of the preparation;
  • age younger than 3 years (for the treatment of recurrent or progressive malignant glioma), or up to 18 years (with malignant melanoma or newly diagnosed glioblastoma multiforme).

wary drug Temodal prescribed to elderly patients older than 70 years, the presence of hepatic failure, as well as in severe stages of the flow of various gynecological diseases.

Side effects of the drug Temodal

In their comments on Temodal patients reported the following side effects of the drug:

  • CNS: impaired perception and coordination, dizziness, confusion, fatigue, insomnia, fainting, memory impairment, neuropathy, a disorderspeech, hallucinations, amnesia, depression, tremors, behavioral mental disorders, epilepsy.
  • From the digestive system: bloating, weight loss, nausea, constipation, vomiting, diarrhea, appetite loss, fecal incontinence, anorexia, gastroenteritis, hyperglycemia, hemorrhoids, dysfunction of the liver, indigestion.
  • Since the cardiovascular system: hypertension, arrhythmias, edema, tachycardia.
  • From the circulatory system: neutropenia, anemia, leukopenia, small hemorrhages in the mucous membranes.
  • part of the respiratory system: bronchitis, dyspnea, pneumonia, bronchospasm, pulmonary edema.
  • With the genitourinary system: herpes, urinary incontinence, candidiasis, decreased libido, vaginitis, painful ejaculation, impotence, Cushing's syndrome, uterine bleeding.
  • part of the skin and subcutaneous tissue: pigmentation disorders, rash, erythema, alopecia, dry skin or dermatitis.


recommended that a prophylactic antiemetic therapy Before taking Temodal against the background of radiation therapy and during adjuvant treatment of glioblastoma multiforme.If during treatment with Temodal patient has nausea or vomiting, further use of the drug should also be accompanied by antiemetic therapy.

patients of childbearing age throughout the course of treatment with Temodal, and within six months after its completion should use reliable methods of contraception.

Because of the increased risk of infertility in the treatment of drug Temodal before therapeutic course the doctor should discuss with patients the possibility of male sperm cryopreservation.

If the contents of the capsule hit the skin or mucous membranes, they should immediately wash with plenty of running water.

Such side effects of Temodal as excessive fatigue and drowsiness, may adversely affect the patient's ability to drive vehicles or perform hazardous activities that require high concentration and speed of reaction from him.


Product description posted on this page is a supplement and a simplified version of the official version of the annotations to the drug.The information is provided for informational purposes only and is not a guide to self-medication.Before using the product you should consult with a specialist and to get acquainted with the instructions approved by the manufacturer.

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