Tamoxifen - instruction , application reviews


1. composition and the form of

2. Pharmacological Effects of Tamoxifen

3. Indications for Use Tamoxifen

4. tamoxifen for

instructions5. Contraindications Tamoxifen

6. Tamoxifen: side effects

7. Cautions

8. drug interaction Nolvadex

Tamoxifen - an antitumor drug with non-steroidal anti-estrogen effect.It reduces inflammation, stops tumor growth and promotes the release of pituitary hormones.In the role of the active ingredient of the drug tamoxifen citrate acts.

composition and the form of

Tamoxifen is issued by the manufacturer in the form of film-coated tablets.Each of them contains 10, 20 or 40 mg of tamoxifen citrate.Auxiliary components: cellulose, sodium starch, lactose, magnesium stearate, povidone.shell composition: titanium dioxide, polyethylene glycol, lactose, hypromellose.The packaging - 10, 30 or 50 tablets.

Pharmacological Effects of Tamoxifen

Tamoxifen is a nonsteroidal anti-tumor drugs.It helps stop cell hypertrophy, to stop

the synthesis of tumor tissue and block the formation of tumors.Frequent good reviews of tamoxifen as an effective drug, prevents the appearance of tumors in the body.

This drug with the first application blocks the negative effects of estrogen in a few weeks.Tamoxifen does not cause side effects associated with excessive growth of tissue and increase cell volume.It is rapidly absorbed in the body and begins to operate in half an hour after administration.

Men suffering violation ejaculation, the drug can lead to increased concentrations of testosterone and estrogen in the blood.

Indications for Use Tamoxifen Tamoxifen By

instructions prescribed to treat a variety of cancers: melanoma, breast cancer, endometrial cancer, ovarian cancer, sarcoma, prostate cancer and kidney cancer.

Positive feedback received Tamoxifen as an effective therapeutic agent used in the treatment uzlovidnyh formations in the soft tissues and tumors of various etiologies.

tamoxifen for

instructions tamoxifen should be started with 20 mg twice a day, after which the dose is increased to 40 mg two or three times per day.The duration of treatment - from 1 to 3 months.Tamoxifen should be carried out in conjunction with radiation therapy and drugs is to stop cell division.

According to the instructions, Tamoxifen must be taken orally, drinking plenty of fluids.The daily dose is divided into two stages - in the morning and evening.

Contraindications Tamoxifen

contraindications to tamoxifen include: liver and kidney failure, leukopenia, severe stage of heart disease, thrombosis, cataracts, hypersensitivity to the components of the drug, pregnancy, lactation period.

wary Tamoxifen is prescribed for diseases of the brain, thrombocytopenia, thrombocytosis and hypercalcemia.

In addition, tamoxifen can not be combined with the administration of drugs containing hormones.

Tamoxifen: side effects

According to reviews of tamoxifen, the drug can trigger the development of the following side effects:

  • From the digestive system: dyspepsia, nausea, vomiting, weight gain, loss of appetite, diarrhea, liver disease, cholestasis.
  • With the genitourinary system: burning and itching of the genital organs, uterine bleeding, reduced potency, painful vaginal, cystic tumors.
  • CNS Tamoxifen leads to side effects following lines: confusion, dizziness, fainting, drowsiness, and headaches.
  • Cardio-vascular system: phlebitis, thrombosis, edema.
  • From the circulatory system: thrombocytopenia, leukopenia, thrombosis.
  • From a sight organ: keratopathy, retinopathy, cataracts.
  • Other effects: increased body temperature, pain in the bones and lesions.

In some cases, can cause side effects Tamoxifen allergic: urticaria, alopecia, skin rash, dermatitis, flushing of the skin, bronchospasm.


The instructions to Tamoxifen indicated that the drug can be administered to patients only after the following diagnostic tests: blood tests, gynecological diagnosis, examination of renal function and liver, hemoglobin levels and indicators of cholesterol, blood pressure and eye examination.

According to reviews of tamoxifen, it could trigger an unscheduled ovulation, so throughout the course of treatment for women of childbearing age are advised to take reliable contraception.

During tamoxifen patients should be particularly careful when driving and while the complex devices.

In a joint application with drugs that affect blood clotting, a correction of the dosage of Tamoxifen.

Drug interaction Nolvadex

When co-administered with allopurinol Tamoxifen may develop hepatotoxicity and to aminoglutethimide - reducing tamoxifen concentration in the blood.

By combining tamoxifen with coumarin derivatives increases the risk of anticoagulant action, and with cytostatics - increases the likelihood of thrombus formation.

tamoxifen treatment during treatment with mitomycin C increases the risk of this disease as hemolytic-uremic syndrome.

Patients taking Tamoxifen in conjunction with warfarin, there is likely to develop a dangerous clinical hematoma, hematuria, and prolongation of the prothrombin time.

When combined bromocriptine and tamoxifen may increase the dopaminergic action of the first.Rifampicin

capable of lowering the concentration of Tamoxifen in the blood plasma, and estrogens - reduce its therapeutic effect.


Product description posted on this page is a supplement and a simplified version of the official version of the annotations to the drug.The information is provided for informational purposes only and is not a guide to self-medication.Before using the product you should consult with a specialist and to get acquainted with the instructions approved by the manufacturer.

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