12 August

Remicade - instruction , application reviews

Contents:

1. Pharmacological properties and indications for use

2. Instruction Remicade

3. Contraindications and side effects

4. Precautions Remicade treatment

Remicade - a drug group of selective immunosuppressive agents, the active substance is infliximab.Remicade is produced as a lyophilized powder for preparation intended for intravenous administration solution.

Remicade One vial contains 100 mg infliximab, and the following auxiliary ingredients: sodium phosphate monobasic and dibasic, polysorbate 80, sucrose.

Pharmacological properties and indications for use

main component Remicade - infliximab - a hybrid compound of the human and mouse IgG1 class of antibodies.This material has a broad spectrum of biological effects which are mainly directed to the reaction of the immune system.In addition, infliximab is capable of interacting with a biological compound that plays a significant role in the development of autoimmune and inflammatory diseases, and inhibit its activity.

According to the instructions, Remicade can be used in the treatment of the following diseases:

  • rheumatoid arthritis;
  • psoriatic arthritis;
  • ankylosing spondylitis;
  • psoriasis;
  • Crohn's disease in children, adolescents and adults;
  • ulcerative colitis.

Instruction Remicade

the treatment Remicade is recommended to use an intravenous drip injection.The drug should be administered for at least two hours, wherein the rate of introduction Remicade should be no more than 2 ml per minute.For administration must use special infusion system equipped with non-pyrogenic sterile filter.Dosage treatment Remicade depends on the indications and the patient's response to the drug.

In rheumatoid arthritis assigned initial dose (3 mg / kg) for one injection, is then inserted through the two weeks, six weeks, and then - once every eight weeks.Remicade treatment in this case is carried out in combination with methotrexate.If after 12 weeks of treatment no improvement occurs, the issue of elimination of the drug.

In psoriatic arthritis or ankylosing spondylitis initial dose is 5 mg / kg.Repeated injections made after two and six weeks, and then every six to eight weeks.The composition of the treatment of psoriatic arthritis include methotrexate.In patients with ankylosing arthritis after the second administration assesses the effect of the treatment of Remicade, and in the absence of positive dynamics of injections are usually overturned.

the treatment of Crohn's disease, occurring in an active form, administered 5 mg / kg dose.In the absence of the effect after two weeks of therapy is terminated.If the decision to continue treatment, Remicade appoint one of the following schemes:

  • 5 mg / kg at two and six weeks, and then - once every eight weeks;
  • 5 mg / kg administered repeatedly only for recurrent disease, with injections made not earlier than 16 weeks after the first injection.

Similarly treated and Crohn's disease with fistula formation, but the reviews of Remicade by experts indicate that the results of treatment in this case should be assessed not after the first and after the third injection.

Contraindications and side effects

The instructions to Remicade contain the following contraindications to the use of the drug:

  • idiosyncrasy;
  • during pregnancy and lactation;
  • children up to 18 years (in the treatment of Crohn's disease - up to 6 years);
  • heart failure, moderate or severe;
  • sepsis;
  • expressed infection or abscess.

Reviews of Remicade and research data indicate that the drug can cause the following side effects:

  • dizziness, headache, anxiety, nervousness, apathy, lethargy, depression, amnesia, psychosis;
  • conjunctivitis, endophthalmitis, keratoconjunctivitis;
  • urinary tract infections (in particular, vaginitis, pyelonephritis) edema;
  • shortness of breath, bronchitis, pleurisy, pneumonia, pulmonary edema, upper respiratory tract infection, sinusitis, bronchospasm, epistaxis;
  • bruising, petechiae, hot flushes, palpitations, syncope, thrombophlebitis, hypotension and hypertension, vasospasm, arrhythmias, bradycardia, cyanosis, lymphocytosis, the peripheral blood circulation, anemia, lymphadenopathy;
  • leukopenia, thrombocytopenia, neutropenia;
  • nausea, diarrhea, abdominal pain, constipation, dyspepsia, cheilitis (inflammation of the skin), gastroesophageal reflux disease, cholecystitis, diverticulitis, abnormal liver function;
  • dry skin, rash, itching, sweating, warts, birthmarks, seborrhea, fungal dermatitis, furunculosis, alopecia, hyperkeratosis, bullous rash, violation of skin pigmentation;
  • antibody formation, the development of infections, lupus syndrome, periorbital edema, myalgia, arthralgia.

As pointed out reviews, Remicade infusion is able to provoke pain syndrome, which is characterized by pain in the chest, and also cause a number of other reactions of varying severity.

Precautions Remicade treatment

Before the appointment of Remicade therapy should be carried out abscesses and manifest (symptomatic) infection.If after the injection, the patient begins to develop a severe infection, repeated injections are not administered.In addition, the therapy is canceled, and when a patient signs of liver damage.

In order to prevent allergic reactions when administered Remicade to simultaneously use paracetamol or antihistamines.

women during treatment must use reliable contraception.It should also be noted that the safety and efficacy data in pediatrics Remicade not available, therefore, this drug is not recommended for treating children.

Attention!

Product description posted on this page is a supplement and a simplified version of the official version of the annotations to the drug.The information is provided for informational purposes only and is not a guide to self-medication.Before using the product you should consult with a specialist and to get acquainted with the instructions approved by the manufacturer.

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