Nimesulide - instruction , application reviews


1. Pharmacological properties

2. Indications for use of nimesulide

3. Guide to nimesulide

4. Contraindications and side effects

Nimesulide - a drug NSAID group (non-steroidal anti-inflammatory drugs), which has anti-inflammatory effect.Nimesulide release tablets and 100 mg for oral suspension, also containing 100 mg in a single bag.

Pharmacological properties

Nimesulide has a pronounced anti-inflammatory, as well as a mild analgesic and antipyretic activity weak.As indicated in the instruction, Nimesulide is a selective inhibitor of cyclooxygenase-2.Thus, the anti-inflammatory mechanism of drug action based on the inhibition of prostaglandin synthesis: the active drug substance inhibits cyclooxygenase-2 preferably, thereby the synthesis of prostaglandins suppressed mainly in inflammation, and to a lesser extent - in the kidney and gastric mucosa.

addition, nimesulide inhibits the formation of free radicals, without impacting the processes of hemostasis and phagocyt

osis.and it has the ability to inhibit the release of myeloperoxidase in the mechanism of action of anti-inflammatory drug of considerable importance.

maximum plasma concentration of the drug is achieved within one to two hours after ingestion of nimesulide suspension or tablets.Excreted drug almost completely eliminated within 24 hours.With prolonged use of nimesulide accumulation (storage) of the drug was observed.

Indications for use of nimesulide

According to the instructions, Nimesulide is used to relieve pain and inflammation in the treatment of the following diseases and pathological conditions:

  • osteoarthritis, extra-articular rheumatism and rheumatoid arthritis;
  • osteoarthritis, tendonitis, bursitis;
  • gynecological diseases;
  • infectious and inflammatory diseases;

injuries of different origin.

As pointed reviews of nimesulide, the drug effectively relieves pain and inflammation in the postoperative recovery period.

Guide to nimesulide

drug dosage is calculated individually based on the evidence, the general condition of the patient and the severity of pain and inflammation.

Dose Nimesulide suspensions and tablets for children is determined based on the rate of 1.5 mg per kg body weight.The maximum daily dose of the drug thus should not exceed 5 mg per 1 kg of body weight.The frequency of administration for children preparation - two or three times a day.Adults appoint 100-200 mg (one or two tablets or suspensions sachet) twice a day.

Contraindications and side effects

Contraindications to the use of nimesulide are hypersensitivity to the active substance of the drug nimesulide and other NSAIDs, including aspirin, children up to 12 years, during pregnancy and lactation.Nimesulide is contraindicated in patients with renal failure, hepatic failure, moderate to severe degree of gastric ulcer and duodenal ulcers, as well as acute bleeding of the gastrointestinal tract.

In addition, the drug is prescribed with caution in elderly patients and patients suffering from visual impairment, cardiovascular diseases, particularly hypertension, impaired renal function and disorders of the upper GI.With tendency to bleeding and received anticoagulants and antiplatelet agents Nimesulide should also be appointed to restrictions on the dosage and frequency of administration.

As the reviews, Nimesulide may cause the following side effects:

  • dizziness, headache, drowsiness;
  • stomach pain, nausea, heartburn, melena, tarry stools;
  • purpura, petechiae;
  • allergic reactions (urticaria, erythema, rash);

oliguria, edema, fluid retention in the body.

Reviews of nimesulide also indicate that in rare cases, the drug can cause thrombocytopenia development.

Since the drug is able to trigger drowsiness and dizziness should be used with caution when driving vehicles, working with moving machinery, and when performing activities related to the high concentration of attention.

Nimesulide is not recommended to be used in combination with anticoagulants, phenytoin, digoxin, diuretics, cyclosporine, drugs lithium, methotrexate, antihypertensive and oral hypoglycemic agents, and other NSAIDs.


Product description posted on this page is a supplement and a simplified version of the official version of the annotations to the drug.The information is provided for informational purposes only and is not a guide to self-medication.Before using the product you should consult with a specialist and to get acquainted with the instructions approved by the manufacturer.

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