Nevigramon - instruction , application reviews

Nevigramon is a pharmacological drug from the group of antimicrobial agents - fluoroquinolones.

According to the instructions Nevigramon contains in its composition:

  • active ingredient - nalidixic acid( 500 mg);
  • excipients( colloidal silicon dioxide, stearic acid, yellow quinoline, titanium dioxide, gelatin).

Manufacturer produces Nevigramon in the form of hard gelatin capsules of yellow color of 500 mg. Each bottle contains 56 capsules.

Analogues Nevigramona are drugs such as Negra and Nalidixic acid. The active component is the same, while replacing Nevigramon with an analog requires consultation with a specialist to determine the dosage.

Pharmacological action of the drug is due to its bactericidal, bacteriostatic and antibacterial effects. The antimicrobial effect of the drug is particularly pronounced in relation to some gram-negative bacteria( enterobacter, protea, klebsiella).The active component of the drug partially inhibits the synthesis of DNA from microorganisms, thus exh

ibiting bacteriostatic or bactericidal action( this depends on the concentration of the drug and the degree of sensitivity of the microorganisms).

After oral administration Nevigramon is quickly absorbed from the gastrointestinal tract. His metabolism occurs in the liver, and excreted by the kidneys. Bioavailability of nalidixic acid is about 96%.As a result of clinical studies, it was found that the drug is able to penetrate the hematoplacental barrier and enter the breast milk.

Instruction for Nevigramon: indications for use

Nevigramon is recommended for the treatment of genitourinary infections( cystitis, urethritis, pyelonephritis, prostatitis), as well as for a number of digestive system infections that are sensitive to this drug( for example, cholecystitis).

Nevigramon, according to specialists, is recommended to prevent infections after operations on the bladder, kidneys and ureters.

Contraindications to the appointment Nevigramona

Among the contraindications for taking the drug are the following:

  • increased sensitivity to the components included in its composition;
  • Parkinson's disease;
  • marked cerebral atherosclerosis;
  • epilepsy;
  • hepatic or renal insufficiency;
  • deficiency of the enzyme glucose-6-phosphate dehydrogenase;
  • porphyria;
  • children under 12 years;
  • pregnancy( first trimester) and lactation.

It is important to note that with special care Nevigramon can be prescribed to patients aged 12-18 years.

Regarding the drug intake during pregnancy and lactation, at the moment there is no information about the features of its effect on the child. It is known that the active component of the drug is able to penetrate the placenta and affect the developing cartilage tissues of the fetus, so its use in the first trimester of pregnancy, as well as at the 9th month is strictly prohibited. In other cases, its appointment is possible if the potential effect of its intake exceeds the threat to the fetus.

According to the instructions to Nevigramon, this product can penetrate into the mother's milk, so during the period of breast-feeding the drug is not prescribed.

Method of application and dosage of Nevigramone

The average daily dose of the drug for adults is 4 g( two capsules 4 times a day).In this case, the course of therapy should last at least 7 days. If it is necessary to prolong treatment with the drug, it is desirable to reduce its dosage to 500 mg, but the frequency of application should be kept the same - 4 times a day.

For children and adolescents from 12 years of age( provided that their body weight is over 40 kg), the daily dosage should be 50 mg / kg, and it should be divided into 3-4 doses.

According to the instructions, the drug is recommended to be taken orally( inside) 60 minutes before meals.

Reviews of Nevigramone: side effects and overdose

Nevigramon, as a rule, rarely provokes negative reactions from the body systems. According to reviews about Nevigramone, the drug sometimes causes frustration on the part of the central nervous system: drowsiness, weakness, headaches, dizziness. There is information that in some cases there may be convulsions, psychosis, increased intracranial pressure( this is mainly the case if there are predisposing diseases of the nervous system).

Very rare cases of paralysis of the sixth pair of cranial nerves due to drug administration are described. Although the exact mechanism of this reaction is not known, but this symptomatology passes after its withdrawal.

Reception Nevigramona can cause the development of side effects from the body of vision - diplopia, difficulty focusing, reducing visual acuity. In addition, there is information about the violation of color perception of patients. But these phenomena occur after the drug is discontinued or when its dosage is reduced.

There may also be a violation of the gastrointestinal tract - nausea, diarrhea, vomiting.

According to reviews on Nevigramone, it can develop allergic manifestations: urticaria, rash, itching, eosinophilia. Quite often the drug provokes Quincke's edema or anaphylaxis.

In very rare cases, this drug can promote metabolic acidosis, cholestasis, thrombocytopenia and leukopenia, and also cause photosensitivity reactions( redness of the skin and the appearance of bubbles on it due to sunlight).

Overdose by Nevigramon and analogues of

In case of taking excessive doses of the drug, such negative reactions as:

  • vomiting and nausea may occur;
  • lethargy;
  • increased intracranial pressure;
  • convulsions;
  • psychosis;
  • metabolic acidosis.

In this case, the patient must be placed in a hospital and prescribed symptomatic and supportive therapy.

Additional information

Nevigramon is characterized by the ability to interact with other pharmacological agents. According to the instructions to Nevigramon, he enhances the effect of oral anticoagulants. And taking the drug in combination with other antibiotics( tetracyclines, chloramphenicol, etc.) can weaken its effect.

In a number of experiments on animals it was proved that Nevigramon is able to cause the development of erosions in the cartilaginous tissues of the joints and to provoke the development of arthropathy( more often in animals that have not reached puberty).Given this, this drug should be administered with extreme caution to patients under the age of 18, and if pain occurs in the joints, it should immediately stop taking it.

It is necessary to inform patients receiving treatment with Nevigramon and analogues about the need to avoid direct sunlight on the skin during therapy. In the case of formation of photosensitive reactions, the drug must be discarded.

With regard to the influence of Nevigramon on the ability to drive a car and other mechanisms, the drug can to some extent reduce the concentration and speed of the patient's response, so you should be careful when working with moving machinery and in the case of driving.


1. Instruction for Nevigramon: indications for use

2. Contraindications to the appointment of Nevigramone

3. Method of administration and dosage of Nevigramone

4. Reviews of Nevigramone: side effects and overdose of

5. Overdose by Nevigramon andanalogs

6. Additional information


Description of the drug, placed on this page, is augmented and simplified version of the official version of the annotation to the drug. The information is provided for informational purposes only and is not a guide for self-treatment. Before using the drug, you should consult a specialist and read the instructions approved by the manufacturer.

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