Metamizole sodium( Metamizole sodium) belongs to the group of analgesic narcotics that nonselectively block COX and reduce the formation of Pg from arachidonic acid.
Produced Metamizole sodium capsules, tablets for adults, tablets for children, solution for intramuscular and intravenous administration, rectal suppository for children.
Metamizole sodium, as a derivative of pyrazolone, possesses all the properties characteristic of NSAIDs( non-steroidal anti-inflammatory drugs).The drug has antipyretic and analgesic effects on the body. It also produces a weak spasmolytic effect on the smooth muscles of the biliary and urinary tract. Like other NSAIDs, Metamizol sodium increases the threshold of excitability of thalamic centers of pain sensitivity, greatly facilitating the patient's condition. When taking the drug increases heat transfer in the body. One of the distinctive properties of Metamizol sodium is a mild anti-inflammatory effect, caused by a mild effect on the mucous
According to the instructions for the drug, it is recommended to prescribe the use of Metamizol sodium in the following conditions:
In the conditions described above, Metamizol sodium is used in the following dosages:
If there is a need to administer a dose in excess of 1 g, intravenous injections are made if there is a technique for performing anti-shock therapy. With the introduction of such a dose of Metamizol sodium, a sharp decrease in blood pressure is possible due to the rapid introduction of the solution into the vein. Therefore, intravenous administration of the drug is slow, introducing no more than 4 ml of solution per minute. The patient is placed in the "lying" position and, controlling the frequency of breathing, heart rate and blood pressure, the drug is administered.
When using a rectal suppository, the dosage of the drug is recommended for adults: 300, 650 and 1000 mg. For children, special children's suppositories are used in a dosage of 200 mg. For children of different age, the appropriate dosage of the drug is selected: toddlers from 6 months.up to 1 year for 100 mg, children 1-3 years for 200 mg, children from 3 to 7 years up to 400 mg, at the age of 8-14 years - up to 600 mg. Introducing the suppository, you need to ensure that the child remained lying in bed.
In the case of metamizol sodium for children under 5 years of age, injections should be administered under the supervision of a physician, because of the likelihood of anaphylactic shock or allergic reactions. Also, amid the use of metamizole sodium, there is a possibility of agranulocytosis, which is manifested by fever, chills, difficulty swallowing, sore throat, etc.
Metamizole sodium is not recommended in the following conditions:
With extreme caution and only under specific instructions use this medication during the neonatal period.
With the use of Metamizole sodium, various side effects may occur:
In medical practice, cases of metamizol sodium overdose, manifested by nausea, oliguria, paralysis of respiratory muscles, vomiting, gastralegia, hypothermia, dyspnea, lowering of blood pressure, tachycardia, tinnitus, impaired consciousness, drowsiness, delirium, acute agranulocytosis, acute renal or hepaticinsufficiency, hemorrhagic syndrome, convulsions, etc. In case of manifestation of this symptomatology, it is necessary to take the following urgent measures: rinse the stomach, give the patient an activated charcoal, withlaxative laxatives and seek emergency medical care. Medical workers with an overdose Metamizol sodium conduct forced diuresis, hemodialysis. In case of convulsive syndrome development, diazepam and high-speed barbiturates are injected intravenously.
When injections are introduced, it is prohibited to mix Metamizol sodium with other medicines in one syringe, in view of the high probability of developing pharmacological incompatibility.
1. Pharmacological action of
2. Indications for use Metamizole sodium
3. Contraindications to the use of Metamizole sodium
Description of the drug, placed on this page, is a supplemented and simplified version of the official version of the annotation to the drug. The information is provided for informational purposes only and is not a guide for self-treatment. Before using the drug, you should consult a specialist and read the instructions approved by the manufacturer.
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