Metamizole - instruction , application reviews

Metamizole sodium( Metamizole sodium) belongs to the group of analgesic narcotics that nonselectively block COX and reduce the formation of Pg from arachidonic acid.

Produced Metamizole sodium capsules, tablets for adults, tablets for children, solution for intramuscular and intravenous administration, rectal suppository for children.

Pharmacological action

Metamizole sodium, as a derivative of pyrazolone, possesses all the properties characteristic of NSAIDs( non-steroidal anti-inflammatory drugs).The drug has antipyretic and analgesic effects on the body. It also produces a weak spasmolytic effect on the smooth muscles of the biliary and urinary tract. Like other NSAIDs, Metamizol sodium increases the threshold of excitability of thalamic centers of pain sensitivity, greatly facilitating the patient's condition. When taking the drug increases heat transfer in the body. One of the distinctive properties of Metamizol sodium is a mild anti-inflammatory effect, caused by a mild effect on the mucous

membrane of the gastrointestinal tract and on water-salt metabolism( retention of Na + and water).The effect of taking the drug is observed after 20-40 minutes after administration, and the maximum effectiveness is noted after 2 hours.

Indications for use Metamizole sodium

According to the instructions for the drug, it is recommended to prescribe the use of Metamizol sodium in the following conditions:

  • febrile syndrome( posttransfusion complications, infectious and inflammatory diseases, development of the syndrome from insect bites - bees, mosquitoes, gadflies, etc.).
  • weak and moderate pain syndrome, in particular neuralgia, myalgia, biliary colic, arthralgia, intestinal or renal colic, burns, trauma, decompression sickness, orchitis, shingles, sciatica, postoperative pain syndrome, myositis, algodismenorea, headache and toothacheetc.

In the conditions described above, Metamizol sodium is used in the following dosages:

  • 2-3 times a day, inside 250-500 mg, the maximum permissible single dose is 1g and 3g per day.
  • for children aged 2-3 years, a single dose of 50-100 mg, at the age of 4-7 years - up to 200 mg, at the age of 8-14 years - 200-300 mg, the number of receptions - 2-3 times per day. Children younger than 1 year Metamizole sodium is administered only intramuscularly. Before the introduction, the solution should be heated to the body temperature, usually it is done by holding it for a couple of minutes in the palm of your hand.

If there is a need to administer a dose in excess of 1 g, intravenous injections are made if there is a technique for performing anti-shock therapy. With the introduction of such a dose of Metamizol sodium, a sharp decrease in blood pressure is possible due to the rapid introduction of the solution into the vein. Therefore, intravenous administration of the drug is slow, introducing no more than 4 ml of solution per minute. The patient is placed in the "lying" position and, controlling the frequency of breathing, heart rate and blood pressure, the drug is administered.

When using a rectal suppository, the dosage of the drug is recommended for adults: 300, 650 and 1000 mg. For children, special children's suppositories are used in a dosage of 200 mg. For children of different age, the appropriate dosage of the drug is selected: toddlers from 6 months.up to 1 year for 100 mg, children 1-3 years for 200 mg, children from 3 to 7 years up to 400 mg, at the age of 8-14 years - up to 600 mg. Introducing the suppository, you need to ensure that the child remained lying in bed.

In the case of metamizol sodium for children under 5 years of age, injections should be administered under the supervision of a physician, because of the likelihood of anaphylactic shock or allergic reactions. Also, amid the use of metamizole sodium, there is a possibility of agranulocytosis, which is manifested by fever, chills, difficulty swallowing, sore throat, etc.

Contraindications to the use of sodium metamizole

Metamizole sodium is not recommended in the following conditions:

  • hypersensitivity to the drug;
  • hepatic or renal insufficiency;
  • oppression of hematopoiesis( selected types of neutropenia, agranulocytosis);
  • hereditary hemolytic anemia;
  • "aspirin" asthma;
  • pregnancy( especially in the early stages), lactation period;
  • anemia, leukopenia.

With extreme caution and only under specific instructions use this medication during the neonatal period.

With the use of Metamizole sodium, various side effects may occur:

  • allergic reactions: angioedema, urticaria, extremely rarely - malignant exudative erythema, anaphylactic shock, Lyell's syndrome, bronchospastic syndrome;
  • from the urinary system: oliguria, impaired renal function, anuria, interstitial nephritis, proteinuria, urine staining in red;
  • from the hematopoiesis: thrombocytopenia, agranulocytosis, leukopenia;
  • local reactions: with intramuscular injection, infiltrates are possible at the site of administration;
  • decrease in blood pressure.

In medical practice, cases of metamizol sodium overdose, manifested by nausea, oliguria, paralysis of respiratory muscles, vomiting, gastralegia, hypothermia, dyspnea, lowering of blood pressure, tachycardia, tinnitus, impaired consciousness, drowsiness, delirium, acute agranulocytosis, acute renal or hepaticinsufficiency, hemorrhagic syndrome, convulsions, etc. In case of manifestation of this symptomatology, it is necessary to take the following urgent measures: rinse the stomach, give the patient an activated charcoal, withlaxative laxatives and seek emergency medical care. Medical workers with an overdose Metamizol sodium conduct forced diuresis, hemodialysis. In case of convulsive syndrome development, diazepam and high-speed barbiturates are injected intravenously.

When injections are introduced, it is prohibited to mix Metamizol sodium with other medicines in one syringe, in view of the high probability of developing pharmacological incompatibility.

Contents:

1. Pharmacological action of

2. Indications for use Metamizole sodium

3. Contraindications to the use of Metamizole sodium

Attention!

Description of the drug, placed on this page, is a supplemented and simplified version of the official version of the annotation to the drug. The information is provided for informational purposes only and is not a guide for self-treatment. Before using the drug, you should consult a specialist and read the instructions approved by the manufacturer.

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