Co - renitek - instruction , application reviews


1. composition and the form of Co-Renitec

2. Pharmacological action

3. Analogs Co-Renitec

4. Indications

5. Contraindications to the use of Co-Renitec

6. Dosing

7. Side effects Co-Renitec

8. storage conditions and shelf-life Co-Renitec

Co-renitek - drug combination tool that is used in the treatment of hypertension.This drug has a diuretic and antihypertensive effects.According to the instructions, Koh renitek considered convenient form of drug for the combined purpose of hydrochlorothiazide and enalapril.

composition and the form of Co-Renitec

Currently Ko renitek produced in the form of round yellow pills.

One tablet contains a drug in its composition 20 mg of enalapril maleate, 12.5 mg of hydrochlorothiazide and auxiliary components such as sodium bicarbonate, pregelatinized corn starch, lactose, water, iron oxide yellow dye and magnesium stearate.

Implement medication in blister packs for tablets 7, placed in cartons and plastic bottles to 56 pi


Pharmacological action

main active components of Co-Renitec are enalapril maleate and hydrochlorothiazide.These substances have on the body diuretic and antihypertensive effects.

enalapril is an inhibitor of angiotensin converting enzyme that lowering blood pressure, renal blood flow significantly increases.This component leads to regression of hypertrophy, as well as preserves left ventricular systolic function.Improvement occurs in a standing position and in the supine position without an excessive increase in heart rate.Regarding

hydrochlorothiazide, it stimulates the renin, and this contributes to a more pronounced decrease in pressure.

Ko renitek, in the opinion of medical experts, is a convenient form of medication for co-administration of hydrochlorothiazide and enalapril.This tool takes effect within an hour after oral administration.The maximum pressure drop observed after five to six hours.The duration of exposure generally depends on the dosage consumed.

Analogs Co-Renitec

Today, the most common and most productive analogues Co-Renitec are the following drugs: Berlipril plus Prilenap, enalapril H Enam H, Enap H, Enap NL and Enafarm N.

These analogs Co-RenitecThey have the same composition and pharmacological action.


Ko renitek instructions for use in the treatment of hypertension.

Contraindications to the use of Co-Renitec

Application Co-Renitec and analogues of the drug is not allowed in the following situations:

  • Hypersensitivity to the active and additional drug substances.
  • Individual intolerance to sulfonamide derivatives.
  • Angioedema in history.
  • anuria.
  • period of pregnancy and lactation.

With extreme caution prescribed Ko renitek in coronary heart disease, congestive heart failure, diabetes, aortic stenosis, inhibition of bone marrow hematopoiesis, hepatic or renal failure, bilateral renal artery stenosis, cerebrovascular diseases, severe autoimmune systemic diseases of connective tissue, hyperkalemiaand stenosis of the artery to a solitary kidney.In addition, the Co-renitek according to instructions prescribed with caution in elderly patients, children, as well as persons on a diet with sodium restriction.


Ko renitek taken without regard to meals.Initial dosage is one tablet per day.In some situations, the dose can be increased twice.

just a few days before the start of therapy is necessary to stop the use of diuretics, as it may be symptomatic hypotension.

In case of overdose there is a stupor, severe hypotension and a significant increase in adverse reactions.With regard to the treatment of overdose, it involves the urgent abolition of the drug, gastric lavage, symptomatic and supportive therapy.In case of overdose often resort to intravenous infusion of normal saline.Enalapril is removed from the systemic circulation via hemodialysis.

Side effects Co-Renitec

According to the instructions the drug tolerated very well, but sometimes it can cause any of the following side effects:

  • part of the respiratory system: dyspnea, cough.
  • Since the cardiovascular system: hypotension, palpitations, fainting, chest pain, tachycardia.
  • From the gastrointestinal tract: pancreatitis, nausea, abdominal pain, vomiting, diarrhea, dry mouth, flatulence (bloating), constipation.
  • From the nervous system: headache, fatigue, dizziness, fatigue, drowsiness or insomnia, irritability, paresthesia.
  • From the Musculoskeletal System: arthralgia, muscle cramps.
  • part of the reproductive system: loss of libido, impotence.
  • From the urinary system: renal function and renal failure.
  • Allergic reactions: angioedema swelling of the tongue, lips, legs, throat, glottis and face.
  • Dermatological reactions: itching, rash, rash, Stevens-Johnson syndrome.
  • From the laboratory parameters: hyperuricemia, hyperglycemia, hyper- or hypokalemia, elevated liver enzymes, increased urea in the blood, decrease in hematocrit and hemoglobin.
  • Other: gout, tinnitus, serositis, fever, myositis, myalgia, vasculitis, arthritis, accelerated erythrocyte sedimentation rate, leukocytosis, eosinophilia, photosensitivity.

storage conditions and shelf-life Co-Renitec

According to the instructions, Koh renitek must be maintained in a dry place inaccessible to children at room temperature not exceeding 30 degrees Celsius.

shelf life of the tablets in the bottle - 2 years in blisters - 3 years from the date of issue.


Product description posted on this page is a supplement and a simplified version of the official version of the annotations to the drug.The information is provided for informational purposes only and is not a guide to self-medication.Before using the product you should consult with a specialist and to get acquainted with the instructions approved by the manufacturer.

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