Co-trimoxazole - instruction , application reviews


1. release form of the drug and

2. Pharmacological action

3. Indications Co trimoxazole

4. Method of use and dosing of co-trimoxazoledrug

5. Contraindications and side effects

6. Reviews of co-trimoxazole

co-trimoxazole - a synthetic antibacterial combination product with a wide spectrum of action.

release form and composition

drug co-trimoxazole is the first generation of antimicrobials used in medical practice since the middle of last century.It successfully combines two synthetic ingredients: sulfamethoxazole (a substance from the group of sulfonamides) and trimethoprim (bacteriostatic antibiotic).

co-trimoxazole is produced in the form of:

  • tablets of 120, 480, 960 mg of the active ingredient each;
  • granules for suspension for oral administration with a concentration of 240 mg of active ingredient per 5 ml;
  • already finished (children's) suspension for intake with the amount of active ingredient 240 mg in each 5 mL;

Regardless of its drug dosage fo

rm two active ingredients are combined in a ratio of 5: 1.For example, in a single tablet with the concentration of Co trimoxazole 480 mg of the active ingredient is present 400 mg sulfamethoxazole and 80 mg trimethoprim, and each 5 ml of suspension - 200 mg sulfamethoxazole and 40 mg trimethoprim.

Pharmacological action

co-trimoxazole has a bactericidal, antibacterial and protivoprotozoynoe action.The active ingredients of the drug inhibit the metabolism of bacteria by disrupting the synthesis of dihydrofolate acid and prevent its conversion into tetrahydrofolic acid.And without tetrahydrofolic acid bacteria lose their ability to grow.

To date, co-trimoxazole is active on many species and strains of microorganisms, in particular with respect to staphylococci, streptococci, pneumococci, dysentery and E. coli, typhoid, Proteus.The drug is completely inactive with respect to the spirochete stick Koch and Pseudomonas aeruginosa.

For many years, the combination of sulfamethoxazole and trimethoprim is considered rational because synergies components (joint action) and slow the development of resistance (resistance of microorganisms to the drug).

Indications Co trimoxazole

According to the instructions to co-trimoxazole, a drug used for the following bacterial infections:

  • respiratory tract infections (bronchitis, pneumonia, suppurative processes in the bronchi, lungs, pleural cavity, and others.)
  • Infections Urinarytract (pyelonephritis, cystitis, urethritis, etc.)
  • Urogenital infections (gonorrhea, granuloma inguinale and lymphogranuloma, chancroid, etc.)
  • digestive tract infections (diarrhea of ​​bacterial origin, typhoid fever, dysentery, gastroenteritis, cholecystitis, and others.)
  • infections of the skin (abrasions, blisters soft tissue, birthmarks, acne, etc.)
  • infections of upper respiratory tract (otitis, laryngitis, sinusitis)
  • Surgical infection (sepsis)
  • Other infectious nature of the disease (meningitis, osteomyelitis,brucellosis, purulent inflammation of the brain, toxoplasmosis, as adjuvant therapy - malaria, cholera).

Dosing co-trimoxazole and dosage adjustment

Tablets and suspension of co-trimoxazole is taken orally with meals or after it, washed down with plenty of water.

The instructions to co-trimoxazole hovering over standard dosing regimen for children and adults.The drug is usually taken twice a day, it is recommended to carry out reception at the same time.Single dose for children:

  • over 12 years - 960 mg;
  • from 6 months to 5 years - 240 mg (5 ml suspension);
  • aged 2-6 months - 120 mg (2.5 mg of the suspension).

For adults the single dose is 960 mg (1 tablet of 960 mg of the active substance or two tablets of 480 mg).

The dose can be corrected by a physician taking into account existing disease, the patient's age and severity of the condition.

median duration of treatment 5 days, but it can be increased up to 10-14 days (venereal diseases, urinary tract infections, otitis, bronchitis) optionally, 3-4 weeks (for brucellosis), and even 1-3 months (attyphoid fever, chronic prostatitis).The drug also must be taken two days after clinical symptoms disappear.

Contraindications and side effects

According to the instruction, co-trimoxazole is contraindicated:

  • are hypersensitive to its active and auxiliary components;
  • patients with renal or hepatic impairment;
  • with pernicious anemia and hemolytic;
  • people with severe cardiac disease;
  • in severe hematological diseases.

oral (by mouth) use of co-trimoxazole is contraindicated for children under 2 months (some say up to 6 months).The active components of the drug can penetrate the placenta to the fetus, as well as in breast milk, therefore instructions to co-trimoxazole strictly forbids taking the drug for pregnant and lactating women.

Due to the presence of the drug sulfa component, there is a high risk of unwanted side effects.Each patient thirtieth application of co-trimoxazole is accompanied by allergic skin reactions, mainly rashes and urticaria, much less developed Stevens-Johnson syndrome and toxic epidermal necrolysis.

In some cases, the intake of the drug is observed abdominal pain, bowel disorder, nausea and vomiting.From the blood system may decrease the levels of neutrophils, platelets, hemoglobin and methemoglobin with the urinary system - crystalluria and haematuria.Reception co-trimoxazole sometimes accompanied by headache, very rarely mental disorders.

most adverse effects the drug has on the liver and kidneys.Against the background of the use of co-trimoxazole is rare, but cases of cholestatic hepatitis fixed, non-infectious nephritis, renal tubular necrosis.

In rare cases, co-trimoxazole interferes with the thyroid gland, causing metabolic disorders such as hypoglycemia and hyperkalemia.

Reviews of co-trimoxazole

According to reviews, Co-trimoxazole is a moderately effective antibacterial agent, he copes with intestinal infections, urinary tract infections, but the most effective action of the drug is in the fight against respiratory tract infections.

Negative comments about co-trimoxazole mainly deal with its side effects.Some patients report the presence of headaches, rashes and stomach upset during treatment with the drug.People with kidney and liver diseases are talking about deterioration of health after the application of co-trimoxazole.

Physician reviews of co-trimoxazole confirm satisfactory efficacy of the drug to the instructions stated in the species and strains of bacteria.But at the same time the doctors confirm the fact that in our time there is a new generation of antibacterial drugs with a narrower spectrum of activity and a lower risk of side effects.


Product description posted on this page is a supplement and a simplified version of the official version of the annotations to the drug.The information is provided for informational purposes only and is not a guide to self-medication.Before using the product you should consult with a specialist and to get acquainted with the instructions approved by the manufacturer.

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