Clexane - instruction , application reviews


1. Indications

2. Instruction Kleksanu

3. Clexane Application of pregnancy and breastfeeding

4. Contraindications and side effects

Clexane - a drug that belongs to the group of anticoagulants of direct action and is used for the treatment and prevention of thrombosis and embolism.The active ingredient is sodium Enoxaparin Clexane.The tool is available as a solution for injection pre-filled syringes.One syringe contained 20, 40, 60, 80 or 100 mg of active ingredient enoxaparin sodium.


According to the instructions, Clexane is used to prevent venous thrombosis, embolism, and thromboembolism:

  • in patients after acute therapeutic diseases are on bedrest (severe acute infection, acute respiratory or heart failure, chronic heart failure, rheumaticacute form of the disease in combination with thrombotic risk factors);
  • in surgical interventions;
  • during hemodialysis (for the duration of the session to four hours).

Clexane is also used for the treatment of d

eep vein thrombosis, coupled or not combined with pulmonary embolism, unstable angina and myocardial infarction, including acute myocardial infarction in patients assigned to medical treatment or coronary intervention.

Instruction Kleksanu

According to the instructions, Clexane should be administered by deep subcutaneous producing injection alternately to the left and right areas of the abdominal wall.The tool can not be used for intramuscular injection.When using Clexane 0.4 and 0.2 mL syringe prior to injection of the air bubbles are not removed in order to avoid the loss of drug.

In order to prevent venous thrombosis and embolism in patients on bed rest after acute therapeutic diseases, appointed Clexane 0.4 ml once a day for 6-14 days.

In order to prevent venous thrombosis and embolism in surgical intervention in the case of general surgical operations Clexane is administered at a dose of 20 mg once a day for two hours prior to surgery.Patients with high risk of thrombotic and embolic Clexane administered 0.4 ml once a day for 12 hours prior to surgery or 30 mg twice a day (administered 12-24 hours after the operation).The drug used in average about 7-10 days, but if necessary therapy is continued until such time as the patient has the risk of venous thrombosis and embolism.So, after orthopedic surgery Clexane 0.4 ml administered once daily for up to 5 weeks.

To prevent thrombus formation during hemodialysis Clexane administered in a dose of 1 mg per 1 kg of body weight.When there is a high risk of bleeding dose is reduced by half (0.5 mg / kg) or 0.75 mg.

When treating deep vein thrombosis daily dose is set based on the rate of 1.5 mg per 1 kg body weight (injection produced once per day) or 1 mg per 1 kg of body weight (twice per day).According to the reviews of Kleksane, duration of therapy is about 10 days.

the treatment of angina and myocardial infarction Clexane administered for 2-8 days in a dose of 1 mg / kg of body weight every 12 hours while the use of acetylsalicylic acid (100 to 325 mg once a day).

the treatment of myocardial infarction with ST-segment elevation course of injections begin with intravenous bolus injection at a dose of 30 mg.Not later than 15 minutes after the injection is administered another dose Clexane, which is set based on the rate of 1 mg per kg body weight.Subsequent injections performed every 12 hours in a dose of 1 mg / kg body weight.

Clexane Application of pregnancy and breastfeeding

Clexane during pregnancy can be assigned only when the expected therapeutic effect for the mother is higher than the potential risk to the fetus.Information about whether enoxaparin sodium crosses the placental barrier during pregnancy, no.If necessary, use Clexane during lactation should stop breastfeeding.

Contraindications and side effects

The instructions to Kleksanu contain the following contraindications:

  • hypersensitivity to enoxaparin sodium, as well as heparin and its derivatives;
  • age of 18 years;
  • diseases, disorders and conditions, accompanied by a high risk of bleeding, such as hemorrhagic stroke, aortic aneurysm or cerebral vessels, enoksaparin- or heparin-induced thrombocytopenia in severe, uncontrollable bleeding.

drug with caution apply at:

  • renal and / or hepatic insufficiency;
  • gastric ulcer and duodenal ulcers, or other erosive and ulcerative lesions of the gastrointestinal tract;
  • severe diabetes;
  • hemorrhagic or diabetic retinopathy;
  • severe vasculitis;
  • hemostasis disorders;
  • bacterial endocarditis;
  • uncontrolled hypertension severe;
  • conduct of epidural or spinal anesthesia;
  • pericarditis or pericardial effusion;
  • severe injuries (especially the central nervous system);
  • intrauterine contraception;
  • open wounds with a large wound surface;
  • concomitant use of drugs affecting hemostasis.

addition, Clexane prescribed with caution in the postpartum recovery period, and after recently undergoing neurological or ophthalmological surgery, ischemic stroke, and spinal tap.Appointment of Clexane in pregnancy patients with artificial heart valves is not recommended.

As indicated data from clinical trials and reviews of Kleksane, the drug can cause the following side effects:

  • bleeding;
  • thrombocytopenia;
  • skin rashes;
  • allergic reactions, including systemic nature.

When using Clexane may also experience local reactions such as pain at the injection site, bruising, rarely - necrosis of the skin.Also reviews of Kleksane coming from experts, indicate a fairly high risk of osteoporosis in the case of long-term drug treatment.


Product description posted on this page is a supplement and a simplified version of the official version of the annotations to the drug.The information is provided for informational purposes only and is not a guide to self-medication.Before using the product you should consult with a specialist and to get acquainted with the instructions approved by the manufacturer.

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