Casodex - instruction , application reviews

Contents:

1. active substance

2. Product form

3. Composition

4. Indications

5. Contraindications

6. dosage and Administration

7. Side effects

8. Cautions

9. Conditions and terms

Casodex - a non-steroidal anti-androgenic drug with antitumor activity.

active substance

Bicalutamide (Bicalutamide).

Product form

Casodex is available in tablet form.Medications sold in blister packs (Table 14. Each) are placed in cardboard boxes for two pieces.

Composition

Tablets

Table 1.

Bicalutamide

50 mg to 150 mg

Excipients: magnesium stearate, lactose monohydrate, povidone, sodium carboxymethyl starch, purified water.

shell composition: titanium dioxide (E171), macrogol 300, hypromellose.

Indications Indications for Casodex purpose are the following diseases:

  • conjunction with surgical castration or analogue of GnRH (gonadotropin-releasing hormone) for the treatment of prostate cancer (for the dosage of 50 mg).
  • as monotherapy for the treatment of patients with prostate cancer (non-metastatic, locally advanced), when other medical intervention is not applicable or not acceptable (for the dosage of 150 mg).
  • as adjuvant therapy or immediate monotherapy in combination with radiotherapy or radical prostatectomy in patients with locally advanced prostate cancer (for the dosage of 150 mg).

Contraindications Contraindications to receiving the drug are:

  • Children's age and female gender.
  • Joint reception with cisapride, astemizole, terfenadine.
  • Individual hypersensitivity to bicalutamide and other auxiliary components of the preparation.

Casodex is used with extreme caution in patients with functional hepatic impairment, lack of lactase, with individual intolerance of lactose and galactose malabsorption syndrome / glucose.

Dosage and Administration

take Casodex shown in adults and elderly men for a long time (at least for 2 years).The recommended dosing regimen - 150 mg 1 time per day.When the disease progresses the symptoms of the drug should be discontinued.

patients with functional disorders of the kidneys and liver dose adjustment is required.

In patients with severe to moderately severe functional hepatic impairment may experience an increased accumulation of the drug.

Side effects

use of the drug can cause the following side effects:

  • Central nervous system: dizziness, headache, increased drowsiness, insomnia, depression.
  • Cardiovascular system: congestive heart failure.
  • Digestive system: nausea, vomiting, dry mouth, anorexia, dyspepsia, flatulence, constipation, elevated liver enzymes (transient), jaundice, cholestasis, hepatic failure.
  • Respiratory System: dyspnea, interstitial lung disease.
  • system hematopoiesis : anemia.
  • Urogenital System: nocturia, sexual dysfunction, sexual dysfunction, decreased libido.
  • Skin and appendages : excessive sweating, skin rashes, hirsutism, alopecia, flushing, urticaria, angioedema.
  • Other : hyperglycemia, diabetes, decrease or increase in body weight, pelvic pain, chest pain, gynecomastia, abdominal pain, fever, tenderness of the breast.

Cautions

Given the possibility of slowing down the accumulation and excretion of bicalutamide in patients with functional hepatic impairment, it is advisable from time to time to assess the functioning of the liver.Most of the changes of the body occur in the first 6 months of Casodex therapy.

Patients with disease progression on higher level prostataspetsificheskogom antigen need to consider discontinuation of Casodex.

Patients with lactose intolerance should be informed that the composition of each tablet contains lactose monohydrate (50 mg - 61 mg 150 mg - 183 mg).

Given the existing risk of inhibiting the activity of Casodex cytochrome P450 (CYP3A4), you must exercise caution when coadministered with drugs Casodex mainly metabolized with the participation of CYP3A4.

the appointment Casodex patients receiving coumarin anticoagulants requires regular follow-up of the prothrombin time.

Bicalutamide is contraindicated in pregnant and nursing mothers.

Casodex does not affect the ability of patients to control vehicles or engage in other potentially hazardous activities requiring psychomotor speed of reaction and concentration.

Terms and Conditions of storage

Store in a cool, dry place at a temperature not exceeding 30 ° C.Keep away from children.Shelf life - 4 years.

Attention!

Product description posted on this page is a supplement and a simplified version of the official version of the annotations to the drug.The information is provided for informational purposes only and is not a guide to self-medication.Before using the product you should consult with a specialist and to get acquainted with the instructions approved by the manufacturer.

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