12 August

Immunoglobulin - instruction , application reviews

Contents:

1. pharmacological action of immunoglobulin

2. Indications

3. Dosage Immunoglobulin

4. Side effects immunoglobulin

5. Contraindications


Immunoglobulin - this immunostimulant drug.The drug is available as a solution for intramuscular and intravenous administration, as well as in the form of powder for injection.

Pharmacological action

Immunoglobulin Immunoglobulin is a globular protein, which is produced by special cells of the human body.Globular protein has been actively involved in the formation of an immune response.

There are different types of proteins, among them - the immunoglobulin G, the E immunoglobulin, human immunoglobulin, Rh immune globulin, immunoglobulin M and A. All of these proteins differ in amino acid composition, structure and functions.

The share of immunoglobulin G accounts for about 70% of whey proteins.The most important immunoglobulin G functions include the ability to penetrate through the placental barrier in order to provide t

he body of the newborn natural passive immunity.Immunoglobulin G is involved in the development of immune response involved in complement activation, enhances phagocytosis.To develop this type of protein requires the mandatory presence of T-lymphocytes.Receiving immunosuppressant exposure and contribute to the suppression of immunoglobulin G.

On Immunoglobulin M accounts for 5-10% of total protein.This type of protein is synthesized in the first newborn body.Immunoglobulin M is the earliest antibodies that fight viruses and Gram-negative bacteria.The protein is involved in complement activation, enhances phagocytosis.This group of proteins include antibodies against Streptococcus, cold agglutinins, agglutinins blood groups, rheumatoid factor.They help attract phagocytes to the site of infection, activation fagotsitoza.Immunoglobuliny M are slabospetsifichnymi - they can simultaneously bind to 5 molecules antigena.Takim way to form large immune complexes, leading to rapid clearance of circulating antigens and does not allow them to attach to the cells.

Among the total number of proteins in the immunoglobulin E accounts for only 0.2%.Immunoglobulin E is present in blood, serum, secretions.Protein provides reliable protection of the body from parasites, promotes activation of tissue basophils induces allergic reactions and anaphylaxis.Immunoglobulin E protects mucous membranes which are in contact with the environment.They are attached to the receptor surface of basophils, mast cells, and if they bind to antigen complex is formed which stimulates the release of cell mediators of allergy.

immunoglobulin norm in children should be: in 1-3 months of life, an infant - 0-2 Re / l, 3-6 months - 3-10 Re / l, in 1 year - 8-20 Re / l, 5years - 10-50 Re / l in 15 years - 16-60 Re / l.Adult immunoglobulin rate is 20-100 Re / l.

on immunoglobulin A, accounting for 10-15% of the total.Immunoglobulin A is found in tears, saliva, gastric secretions, intestinal secretions, lung, vagina, urinary tract, the bronchi.A large amount of protein found in breast milk, through this when breastfeeding your baby provides protection from the first days.This type of protein contributes to the neutralization of bacterial toxins and viruses, and also protects the mucous membranes.

human immunoglobulin differs a high content of antibodies that fight various pathogens.Human immunoglobulin reduces the likelihood of contracting infections in immunocompromised patients, and the lack of replenishment G-antibodies.

Rh immunoglobulin is injected into a woman's body during pregnancy, detection of Rhesus-conflict to prevent Rh sensitization.Protein contributes to the destruction of fetal Rhesus positive red blood cells in maternal circulation, preventing generation protivorezusnyh maternal antibodies.

Indications

Immunoglobulin G is prescribed for liver cirrhosis, infectious diseases, viral and chronic autoimmune hepatitis, dermatomyositis, multiple myeloma, systemic lupus erythematosus, AIDS, rheumatoid arthritis, HIV infections, sepsis, meningitis, sinusitis, cancer pathology, otitis media, pneumonia.

Immunoglobulin E is effective in allergic diseases such as food, drug allergy, hay fever, atopic dermatitis, eczema, bronchial asthma, helminth infections.The drug is also used to assess the development of allergies in children.

human immunoglobulin to be taken in congenital hypogammaglobulinemia, agammaglobulinemia, severe combined immunodeficiency, deficiency of immunoglobulin subclasses of the G, for replacement therapy in myeloma, AIDS in children, chronic lymphocytic leukemia.

Rh immunoglobulin given to women who have Rh negative, in which not produced Rh antibodies.Rh immune globulin is also taken in the case, if you want to terminate a pregnancy by artificial means in women with Rh negative.

Dosing

immunoglobulin preparation is administered by intravenous or intramuscular route.The method of drug administration is determined by the doctor.The rate of immunoglobulin established specialist individually in each case, depending on the diagnosis.

Side effects immunoglobulin

When receiving immunoglobulin specific rules in each case the side effects are extremely rare.As a rule, they disappear almost immediately after the course.

As a result of taking the drug, the patient may appear dry cough, tachycardia, shortness of breath, stomach pain, diarrhea, nausea, cyanosis, pain in the sternum, vomiting, drowsiness, sweating, hiccups.Among the side effects are also noted the occurrence of allergic reaction, back pain, aches in the joints, renal tubular necrosis, increased salivation.

Contraindications The drug is forbidden to take for patients with diabetes, renal failure, anaphylactic shock, acute phase of allergy.Precautions drug is given to pregnant women, lactating, decompensated chronic heart failure, migraines.

Attention!

Product description posted on this page is a supplement and a simplified version of the official version of the annotations to the drug.The information is provided for informational purposes only and is not a guide to self-medication.Before using the product you should consult with a specialist and to get acquainted with the instructions approved by the manufacturer.

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