Izoniazid- instruction , application reviews


1. release form Isoniazid

2. Indications isoniazid

3. Contraindications

4. Guide Isoniazid

5. Side Effects

6. storage

Isoniazid is a synthetic anti-TB drug, exhibits bacteriostatic activity against Mycobacterium tuberculosis.

Isoniazid - the active ingredient of the same name, part of this money and is a derivative of isonicotinic acid.Action This component is aimed at tuberculosis mycobacteria.It should be noted that the active substance is inactive with regard to other common infectious agents.

children Isoniazid is prescribed for a positive reaction to the tuberculin test is not less than 10 mm.The drug is well absorbed from the gastrointestinal tract.Maximum blood concentration means noted after one to three hours after drug administration.

Typically, the drug is well tolerated in adult patients and children.Subject to the therapeutic dosage of isoniazid poisoning occurs only in extremely rare cases.

Product form Isoniazid

The drug is available in tab

let form isoniazid, as well as in the form of injections.The tablets are placed in the package.

In addition, the tool is part of the other combined drugs against tuberculosis.

solution of 10% is realized in ampoules 5 ml each.One pack is placed five vials, and packaging, in turn, placed in cardboard boxes, on one or two pieces each.

Indications isoniazid

In accordance with the instruction of isoniazid, the tool is designed to treat all forms of TB, including reactive and tuberculous meningitis.Isoniazid children and adult patients, and is often included as part of combination therapy.

In Isoniazid manual says that the drug is used for acutely occurring processes included in the complex therapy, along with broad-spectrum antibiotics, quinolones and sulfonamides.

as a prophylactic isoniazid tablets prescribed for persons who are in close contact with patients with active tuberculosis, as well as elderly patients with a positive skin reaction to tuberculin (5 mm) and confirmed by X-ray data.To prevent isoniazid for children up to four years with a positive response of more than 10 mm.


In accordance with the instruction of isoniazid, the tool should not be used in the presence of hypersensitivity to its components, epilepsy and a tendency to seizures, severe kidney and liver failure, poliomyelitis, mental illness, nervous system diseases, hypertension 2-second and third stages, atherosclerosis, asthma, cardiopulmonary diseases 3rd stage cirrhosis, phlebitis (contraindicated for intravenous administration), diseases of the peripheral and optic nerves, eczema on the acute stage, toxic hepatitis in history, myxedema andischemic heart disease.

Guide Isoniazid

This tool is intended for oral administration, as well as for intravenous, vnutrivarikoznogo, and intramuscular administration by inhalation in the form of solution for injection.

treatment regimen in each case is determined individually and depends on the nature of the disease, age of the patient and tolerability.

Tablets Isoniazid is administered in a dosage of 300 mg once daily to adults and children in their teens.Taking the drug should be before a meal.The daily dose of tablets and solution by intravenous administration should not exceed 300 mg.As

prophylactic isoniazid tablets administered at the rate of 5-10 mg per kilogram of body weight per day.Recommended dose be divided into two steps.The duration of prophylactic course of not less than two months.Isoniazid children administered at a dosage rate of 10-20 mg per kg baby weight once a day.The duration of the tablets is determined individually.

For intravenous and intramuscular administration of the daily dose is 10-15 mg per kilogram of body weight.By intramuscular and intravenous agents are usually treated with active TB if the patient have difficulty taking pills associated with intolerance or gastrointestinal disease.

Adult patients and children in their teens 10% solution is administered at the rate of 5-12 mg per kilogram of body weight per day.The duration of the therapeutic course in an average of two to five months.

According to reviews of isoniazid, intravenous administration of the drug is better tolerated in compliance with bed rest for one to two hours after taking the medicine.

is administered intravenously at a tricky and tricky fibro-pulmonary tuberculosis, as well as during preparation for surgery.Inhalation

performed every day 10% solution of 5-10 mg per kilogram of body weight per day.The duration of the therapeutic course may be from one month to six months.

Side effects

In accordance with the review of isoniazid, in the application of the drug at therapeutic doses, the patient may experience headache, pain in the heart, vomiting, nausea, dizziness and allergic reactions.

In some cases, the patient also manifested side effects such as euphoria, sleep impairment, drug-induced hepatitis and psychosis.

In a review of isoniazid notes that isoniazid poisoning can occur at higher drug doses.Among the most common isoniazid poisoning symptoms can be identified drowsiness, nausea, vomiting, dizziness, confusion, dysarthria.In some cases, isoniazid poisoning is fraught with the development of seizures, coma, respiratory disorders and pronounced motor excitation.

While receiving funds should not drink alcohol.Women during pregnancy, the drug is prescribed only under strict indications.

Storage Shelf life Tablets Isoniazid is six years, and the solution in the vials can be stored up to two years.


Product description posted on this page is a supplement and a simplified version of the official version of the annotations to the drug.The information is provided for informational purposes only and is not a guide to self-medication.Before using the product you should consult with a specialist and to get acquainted with the instructions approved by the manufacturer.

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