Difenin - instruction , application reviews


1. Pharmacological action

2. Indications

3. Application Difenin on

instructions 4. Contraindications

5. Side effects

6. Cautions

Difenin - drug comes in tablet form and is used for treatment of epilepsy, trigeminal neuralgia and ventricular arrhythmias.

Pharmacological action

drug has anticonvulsant, analgesic, antiarrhythmic, and muscle relaxant effects.

According to reviews of Difenin, the drug, being an effective anticonvulsant, has no pronounced hypnotic effect, in contrast to many other drugs used in the treatment of epilepsy.To reduce seizure activity resulting in phenytoin - the main active ingredient of the drug, which stimulates the cerebellum, thereby activating the brake path extending to the cerebral cortex.

Viewed drug is able to increase the pain threshold of trigeminal neuralgia.Reviews Difenin indicate that use of the drug reduces the duration of pain attack in this disease, and also reduces the excitation and the frequency of the formation

of repeated discharges.

Providing antiarrhythmic action Difenin reduces abnormal ventricular automaticity, reduces refractory period (the period when the excitable tissue is not able to make his second action potential), reduces the excitability of membranes.

Induction period difenina the main active ingredient in the blood characterized by variability (variability).Thus, the maximum concentration of phenytoin in blood plasma can be observed in a period of from 3 to 12 hours after ingestion.Phenytoin is distributed to all tissues and organs of the body, penetrate into the cerebrospinal fluid affects the central nervous system, and is released from the intestinal gastric juice, saliva, is able to penetrate into breast milk and semen.The placental barrier is not an obstacle for phenytoin.In the treatment of phenytoin, the drug concentration in the blood of mother and fetus are the same.

phenytoin is metabolized by liver enzymes.The half-life is 24 hours.With long-term course of treatment phenytoin completely eliminated from the body for 3 days.


In accordance with the instruction to phenytoin, indications for use of the drug are:

  • epilepsy, such as grand mal seizures, accompanied by loss of consciousness;
  • prevention and treatment of epileptic seizures in neurosurgery;
  • trigeminal neuralgia;
  • cardiac arrhythmias provoked by organic lesions of the central nervous system, or resulting from an overdose of cardiac glycosides.

Application Difenin on

instructions in accordance with the instructions, Difenin must be taken with food or immediately after meals to prevent irritation of the gastric mucosa.

In epilepsy adults take for ½-1 tablet of 2-3 times a day.Children from 5 to 8 years appoint half phenytoin tablets twice a day.Kids after 8 years can be assigned to 1 tablet twice a day.Adjustments to the recommended doses of the drug should deal exclusively with the attending physician.

In the treatment of arrhythmias adults appoint one tablet difenina 4 times a day, while the effect of the therapy can be observed after 3-5 days after initiation of therapy.With the improvement of the patient's dose of phenytoin reduced.

When trigeminal neuralgia patients prescribed the drug for 1-3 tablets per day, depending on the patient's condition.

Contraindications Contraindications to receiving phenytoin are:

  • increased individual sensitivity to the drug;
  • atrioventricular block second and third degree;
  • Stokes-Adams syndrome;
  • cachexia (very dangerous depletion of the body, caused by tumor disease);
  • porphyria (a kind of genetic liver disease);
  • renal or hepatic impairment.

With extreme caution Difenin prescribed to children with symptoms of rickets, diabetics, the elderly, patients with chronic kidney disease and liver, as well as people suffering from chronic alcoholism.

Side effects

Reception phenytoin may be accompanied by the following adverse symptoms:

  • allergic reactions: skin rash, fever.According to the reviews of Difenin, in rare cases, patients developed purple or bullous dermatitis hepatitis.This dermatological manifestations sometimes accompanied by a rash similar to those that are in measles and scarlet fever;
  • disorders of the nervous system: dizziness, headache, incoordination, agitation, confusion, difficulty in breathing, nystagmus, ataxia, insomnia, mood swings, muscle weakness and other;
  • disorders of the digestive system: nausea and vomiting, decreased appetite, constipation, gingival hyperplasia, liver damage, chronic hepatitis;
  • disturbances in the hematopoietic system: leukopenia, thrombocytopenia, megaloblastic anemia, agranulocytosis, etc.


difenina discontinue therapy should be gradual.Abrupt withdrawal of the drug in patients with epilepsy, especially after prolonged use can trigger the development of the syndrome.With the lack of effectiveness of phenytoin, the patient should consult a doctor for the appointment of another antiepileptic drug.

There are reviews of Difenin showing that taking this drug may be associated with suicidal ideation and suicidal behavior.Therefore, by doctors and relatives of the patient should be monitored for the behavior of patients who are prone to suicide.


Product description posted on this page is a supplement and a simplified version of the official version of the annotations to the drug.The information is provided for informational purposes only and is not a guide to self-medication.Before using the product you should consult with a specialist and to get acquainted with the instructions approved by the manufacturer.

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