1. active substance
2. Product form
6. dosage and Administration
7. Side effects
9. Terms and Conditions of storage
ginipral - selective beta2-adrenergic blocker used in obstetric practice.
The drug is available in the form of a round biconvex white tablets and a clear, colorless solution for intravenous administration.
tablets sold in blister packs of 10 pieces, in cardboard packaging (2 blisters in each).A solution for intravenous administration
Auxiliary components: lactose hydrate, copovidone, disodium edetate dihydrate, glycerol palmitate stearate, magnesium stearate, maize starch, talc.
solution for intravenous administration
Auxiliary components: sulfuric acid diluted 2N, disodium edetate dihydrate, sodium metabisulphite, sodium chloride, water for injections.
Indications The indications for the use of tablets is the threat of premature birth (continued infusion therapy).
solution for intravenous use in the following situations:
Contraindications Contraindications to the use of ginipral are:
ginipral also can not be used in the first trimester of pregnancy and lactation.
tablets need to drink a small amount (about 100 ml) of water.
With the threat of premature birth hexoprenaline appoint 500 mg (one tablet) over 60-120 minutes before the end of the infusion.
drug first take 1 tablet every 3 hours, and then every 4-6 hours.The daily dose varies from 2 to 4 mg (4-8 tablets).
solution ginipral introduced only by the intravenous route.The contents of the ampoule (chloride after dilution to 10 ml with isotonic sodium solution) was added over 5-10 minutes using a conventional infusion systems automatically dosing infusion pumps.Dose selected physician on an individual basis.
Acute tocolysis hexoprenaline appoint 10 mg.If necessary, the treatment is sustained infusion techniques.
In the case of massive tocolysis initial dose of 10 mg followed by infusion at a rate of 0.3 g per minute.
With prolonged tocolysis ginipral used as a long-term drip infusion.The administration rate is 0.075 g per minute.
If within 2 days of the fight is not renewed, then the treatment should be continued tablets.
use of the drug can lead to the following side effects:
side effects in newborns are acidosis and hypoglycemia.
Overdose symptoms include arrhythmia in the mother, expressed tachycardia, decreased blood pressure, false angina, headaches, anxiety, increased sweating.
overdose treatment is to apply ginipral antagonists, which are non-selective beta-blockers, completely neutralizing the effect of the drug.
patients with hypersensitivity to sympathomimetics drug should be administered in minimal doses, chosen individually.Hexoprenaline applied in a given situation under constant medical supervision.
during treatment should be carefully monitored cardiovascular functions (blood pressure, heart rate) and mother and child.Prior to and during therapy is recommended to record the electrocardiogram.
In marked decrease in blood pressure or a significant increase in heart rate, you need to reduce the dose.
In the event of false angina, shortness of breath, or symptoms of heart failure treatment Ginipralom should be discontinued immediately.
Use of the drug reduces urine output, so the patient must carefully watch for signs that indicate fluid retention in the body.
During therapy requires regular monitoring of the intestinal activities.Application
hexoprenaline may lead to increased concentrations of glucose in the blood, therefore mothers with diabetes require carbohydrate metabolism control.
Combining medication with corticosteroids may lead to pulmonary edema (especially in the case of patients suffering from kidney disease).During treatment should be strictly limiting fluid intake.Also, the use of salt should be restricted.
Before starting tocolytic treatment should take potassium supplements, since the action of sympathomimetic on the heart muscle increases with hypokalemia.
With prolonged tocolytic treatment is necessary to monitor the state of fetoplacental complex, as well as ensure that no placental abruption.
Concomitant use of sympathomimetic drugs for anesthesia and can cause cardiac arrhythmia.Before using halothane ginipral use should be discontinued.
tocolytic therapy in combination with beta-agonists causes an increase in symptoms accompanying dystrophic myotonia.In this situation, it is recommended to resort to drugs diphenylhydantoin.
Application pills with coffee or tea leads to increased side effects of the drug.
Store away from direct sunlight and children, at a temperature range of 18 to 25 ° C.
tablets Shelf life - 5 years.
shelf life of the solution for intravenous injection - 3 years.
After expiry drug use is strictly prohibited.
Product description posted on this page is a supplement and a simplified version of the official version of the annotations to the drug.The information is provided for informational purposes only and is not a guide to self-medication.Before using the product you should consult with a specialist and to get acquainted with the instructions approved by the manufacturer.
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