Tubulointerstitial nephritis - symptoms, treatment


1. Causes

2. Symptoms tubulointerstitial nephritis

3. Diagnostics tubulointerstitial nephritis

4. Treatment tubulointerstitial nephritis

tubulointerstitial nephritis- heterogeneous group of primary non-specific lesions of the renal tubules and interstitial inflammation spread to all the structure of renal tissue.The disease is infectious, toxic or allergic genesis leads to a decrease of renal function.There are two forms of the disease:

- acute tubulointerstitial

nephritis - a disease in which suddenly developed renal failure due to damage to the renal tubules and surrounding tissue, often as a result of allergic reactions to drugs and infections;

- chronic tubulointerstitial nephritis - any chronic kidney disease, in which damage to the tubules or the surrounding tissue more pronounced than the damage to the glomeruli and blood vessels.This form can be caused by many different diseases and taking certain drugs and herbal infusions.


Acute tubulointerstitial nephritis in more than 95% of cases develop after infectious diseases or as a result of medications that cause allergies or have a direct toxic effect on the kidneys.Other causes of this form of the disease may be bacterial kidney disease (pyelonephritis), malignancies (leukemia and lymphoma), and hereditary diseases.

Chronic tubulointerstitial nephritis - polietiologic disease.It can grow uncured or late diagnosed acute tubulointerstitial nephritis.But most of all causes of this form of the disease is medicaments, household and industrial poisoning, radiation exposure, metabolic disorders, immune-mediated diseases, infections, reflux or obstructive nephropathy and other diseases, including hereditary.

Symptoms tubulointerstitial nephritis

disease occurs in different ways, depending on the form.Symptoms of acute tubulointerstitial nephritis in the form of a rise in body temperature, fever, urticaria rashes, painful urination, bilateral enlargement of the kidneys, the appearance of pus in the urine, and pain in the lower back or side.At the same time in some patients the disease manifests itself a little, and renal failure is detected as a result of laboratory tests.

tubulointerstitial nephritis symptoms in chronic non-specific, developed mostly unnoticed by the patient with a gradual increase.Adults and children with chronic tubulointerstitial nephritis in the form shown general weakness, malaise, fatigue, decreased activity, headache, decreased appetite.Swelling due to fluid retention in the body are usually absent.In the case of a significant deterioration in renal function, there are signs of the acute form of the disease: aching pain in the lumbar region, thirst, dry mouth, frequent urination, increased amounts of urine.

Diagnostics tubulointerstitial nephritis

For diagnosis requires analysis of the history, physical examination findings, and laboratory tests.On tubulointerstitial nephritis in adults and children indicates the content of a small amount of protein, leukocytes and erythrocytes in urine at its reduced density and reduced sodium levels.Also carried out the definition of the maximum relative density of urine, the daily excretion of sodium, calcium, phosphorus, pH and acidity of urine before and after the special loads and do ultrasound of the kidneys.To clarify the diagnosis and treatment of conducting research bacteriological urine culture and make a biopsy of the kidney.

Treatment tubulointerstitial nephritis

Treatment tubulointerstitial nephritis in acute and chronic form is aimed at correcting the etiological factor.In the acute form of the disease kidney function is usually restored after they stopped taking the drug that caused it.At the same time a certain degree of renal fibrosis is usually preserved, and in some cases the damage is irreversible.If the disease was caused by an allergic reaction may corticosteroids to accelerate the healing process of the kidneys.

tubulointerstitial nephritis treatment in the chronic form is in compliance with sparing diet, limiting coffee, spices, fatty and spicy dishes.For detoxification prescribe drinking plenty of fluids and fluid therapy.As a result of urine culture, and on the basis of sensitivity to antibiotics prescribed antibiotics, antifungals or uroseptiki.Also receiving immunostimulants recommended.

success of the treatment of chronic tubulointerstitial nephritis depends on the cause and the ability to recognize and stop the pathological process before irreversible fibrosis formed.Many factors that cause disease (genetic, metabolic, and toxic) can not be corrected.In such cases usually develop end-stage renal failure.


This article is available exclusively in the educational purposes and is not research material or professional medical advice.

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