Microangiopathy - forms, causes , symptoms, treatment


1. Cerebral microangiopathy

2. microangiopathy in diabetes

The disease is conventionally divided into two types, the first time marked thickening of the arterial walls of hyaline character, in the second extendedvenules and capillaries walls thicken.

Most often microangiopathy experts mean precisely those violations that occur in the capillaries (thickening of the walls of the basement membrane and the intima).

microangiopathy can be developed in various diseases, such as diabetes mellitus, connective tissue disorders, infectious nature of the disease and malignant neoplasms.

microangiopathy Quite often accompanied by renal insufficiency, bruising (purpura) and damage to red blood cells (hemolysis).

Cerebral microangiopathy

When cerebral microangiopathy is damage small blood vessels that are responsible for metabolism.

Cerebral microangiopathy most often develops in the presence of chronic cerebrovascular insufficiency.Normal human brain blood flow provided by metabo

lic substrates such as glucose and oxygen.When cerebral microangiopathy for a long period of time there is a deficiency, which in turn leads to the dysfunction of the brain, due to irregularities in the structure of its smallest arteries.

When microangiopathy of the brain white matter lesion occurs diffuse bilateral ischemic.Violation of the normal functioning of the brain can lead to many lacunar infarcts his deep areas or to different Encephalopathies (diffuse brain injury syndrome).

Quite often cerebral microangiopathy develops on the background of arterial hypertension (persistent high blood pressure) and atherosclerosis (hardening of the artery walls and loss of elasticity).

Treatment of the disease is primarily based on the elimination of the causes that resulted in its development, as well as on preventive measures.

microangiopathy in diabetes

development of diabetic microangiopathy is primarily due to increased levels of glucose contained in the blood.In this case there is damage to the capillaries, venules and arterioles, which may have a different localization.

Thus there is a thickening of the basement membrane and deposition of PAS-positive substances in increased amounts.

Clinical manifestations of this form of microangiopathy rather diverse.Firstly there is a decrease amount of output degradation products, caused by difficulties in nutrient intake.That in turn leads to hypoxia, which is often a major symptom of diabetic microangiopathy.

deterioration of the patient's condition is marked with a strong narrowing of vessels, since greatly improved blood sugar levels, which leads to swelling and inflammation of the vessel walls.

most acute manifestations of this form of microangiopathy observed in the kidneys and the eyes (the retina of the eye).

The disease causes nephropathy (30-35% of cases), which is characterized by disruption of the normal functioning of the kidneys.There have kidney swelling, increased protein content in urine and change its specific gravity.Microangiopathy in most cases, this case leads to renal failure.

defeat of the retina of the eyeball is another manifestation of diabetic microangiopathy.The reason for this process is most often serve as vascular disorders, leading to disruption of normal blood supply to the retina.

Treatment of diabetic microangiopathy is based on the normalization of blood glucose levels.Currently there are many drugs can achieve this.

most commonly used for these purposes insulin and drugs that improve the microcirculation of the blood.

inpatient patients assigned to receive angioprotectors, the effect of which is aimed at restoring the vessel walls.In addition high efficiency in the treatment of diabetic microangiopathy have antioxidants, such as selenium / vitamin E, B vitamins and lipoic acid preparations.

microangiopathy is a unique process that can develop into any of the vessels of the internal organs and systems.The only difference is in the degree of severity of the disease, which in turn depends on the anatomical and morphological characteristics of each organism.


This article is available exclusively in the educational purposes and is not research material or professional medical advice.

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