Brucellosis in human - Symptoms , Diagnosis, Treatment


1. Causes of brucellosis in humans

2. Symptoms of brucellosis

3. diagnosis of brucellosis

4. Treatment of brucellosis

brucellosisIt called zoonotic infectious disease that is transmitted to humans from animals.When illness occurs, a severe allergic reaction of the body, affects mainly the heart, nervous and reproductive systems, as well as the musculoskeletal system.

Causes of brucellosis in humans

causative agents of brucellosis are Brucella bacteria.They are stored in water up to six months in soil - up to 3 months, well in colder temperatures.Disinfectants and boiling kill the causative agent of brucellosis in a few minutes.Man transmitted infection most frequently contact, the airborne and alimentary route.By contact infection occurs due to contact with the amniotic fluid of a sick animal to the human skin.Alimentary loss happens due to consumption of infected milk, cottage cheese, cheese of cows, goats or sheep.Rarely brucellosis pathogen is transmitted from o

ne person to another.The disease is prevalent in rural areas, farmers, butchers and veterinarians.

Symptoms of brucellosis

brucellosis incubation period may be from 5 days to several months.It usually takes 12-14 days after infection.Symptoms of the disease very different, especially in the early stages.

Brucellosis in humans begins with the appearance of fever and growth in body temperature, while there may be a severe headache, diarrhea and malaise.When a latent form disease - muscle pain and neck, headache.After completion of the initial stage of brucellosis note the following symptoms:

  • severe constipation;
  • reduction or complete loss of appetite;
  • abdominal pain and joint pain;
  • headache and cramps in the lower back;
  • irritability, weakness, depression;
  • sleep disturbance.

Later the patient can climb high temperature, which decreases after 5 days, increase the spleen, liver and lymph nodes.In milder cases of brucellosis in humans recovery occurs within 3 weeks.Complications are rare, but can lead to inflammation of the bone, gall bladder, testicles, nerve, liver, to the defeat of the heart, meningitis and encephalitis.When the patient is relapsing course of the disease, suggests chronic brucellosis.In this case, the duration of the disease can reach 2-3 years.

Common symptoms of brucellosis:

  • headaches;
  • muscle pain;
  • pain in the joints and the lower back;
  • fever;
  • violation of stool (diarrhea, constipation);
  • weight loss;
  • enlarged lymph nodes and liver;
  • depression.

diagnosis of brucellosis

diagnosis of brucellosis is the differentiation from other diseases, accompanied by prolonged fever, diseases.In acute brucellosis graph of temperature measurement is the wrong one, with the appearance of fever, sweating.Also, the physician should rule out rheumatoid arthritis and rheumatism, tuberculosis focal lesions, gonococcal arthritis, and syphilitic.If you suspect brucellosis check the status of the lymph nodes, liver and spleen.

considered mandatory laboratory diagnostics of brucellosis, including crops cerebrospinal fluid, blood and lymph nodes punctates.Such a diagnosis is carried out in special laboratories, because of the low vyseivaemosti identify the pathogen is very difficult.In recent years, widely used:

  • agregatgemagglyutinatsii reaction that detects Brucella antigens in the blood;
  • Coombs' test, to detect incomplete antibodies in chronic brucellosis;
  • reaction to Wright, the most informative in acute brucellosis;
  • reaction lysis Brucella;
  • sample Burne, with intradermal administration brucellin.

For the most accurate results, use both 3-4 serological method of research, it is called an integrated serodiagnosis.

Treatment of brucellosis

brucellosis Treatment is carried out on an outpatient basis in mild forms, and permanently - in severe forms of the disease.The optimal assignment of two different antibiotics from penetrating through the cell membrane.Provided contraindications apply such a combination:

  • rifampicin and doxycycline;
  • doxycycline and streptomycin;
  • oflaksatsin and rifampicin.

Doses and duration of their admission determined by the physician depending on the patient's weight and severity of the disease.

In the complex treatment of brucellosis used detoxification agents, ATP, soft immunostimulants, methionine.anti-inflammatory drugs are often used - Brufen, indomethacin.For pain relief therapy is well suited as novocaine blockade.

With great care are treated with glucocorticoids.Their purpose is justified in patients with lesions of the CNS, severe inflammatory changes and no effect of anti-inflammatory drugs.In the chronic form of brucellosis prescribe physical therapy, physiotherapy and spa treatment.


This article is available exclusively in the educational purposes and is not research material or professional medical advice.

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