1. metering mode according to the instruction to azathioprine
2. Side effects of the drug
3. Contraindications to the use of azathioprine
Azathioprine -it is a potent immunosuppressive drug with a potent cytotoxic and cytostatic effect.The main scope of the drug is transplantation: the drug is used in combination therapy for the prevention of the possible reaction of transplant rejection.
azathioprine also used in the treatment of chronic active hepatitis, ulcerative colitis, rheumatoid arthritis, heavy flow, systemic lupus erythematosus, myasthenia gravis, dermatomyositis, pemphigus vulgaris, an autoimmune glomerulonephritis, polyarteritis nodosa, idiopathic thrombocytopenic purpura and psoriasis.
The instructions to the azathioprine dosage is not clearly defined by use of the drug as a dose appointed doctor individually, based on the evidence, the severity of the disease, as well as the dosage of both drug
To prevent graft rejection medicament is used at the highest doses: 5 mg / kg two or three times a day.The first stage of treatment lasts one to two months.The preparation was then used at a reduced dose (1 to 4 mg / kg per day) for prolonged period.Treatment can last for several years, and then gradually reduce the dose, watching the reaction of transplant: when the signs of his rejection of the dose again increased to 4 mg / kg per day.
daily dosage rate of the drug in other diseases instruction defined to azathioprine in the range of 1 to 2.5 mg / kg.
Azathioprine has a number of side effects that can affect the cardiovascular system, organs of hematopoiesis and hemostasis process.These include mielodeprescia, which can manifest itself in the form of anemia, leukopenia or thrombocytopenia, macrocytosis and megaloblastic erythropoiesis.
also side effects of the drug can affect the digestive tract and manifest as loss of appetite, nausea and vomiting, abdominal pain, diarrhea, liver dysfunction, erosive and ulcerative lesions of the mouth and lips and cholestatic hepatitis.
show reviews azathioprine received from doctors in transplant recipients drug can cause severe gastrointestinal disease: ulceration of the stomach and duodenum, pancreatitis, necrosis and perforation of the bowel, intestinal bleeding.Prolonged treatment with azathioprine possible toxic hepatitis.
addition, the drug can cause allergic reactions in the form of drug fever or rash, lead to the development of secondary infection, myalgia, arthralgia, panuveitu, alopecia.
In very rare cases, the side effects of azathioprine leads to acute renal failure, acute lung disease, and hemolytic anemia.In rare cases, the drug can cause mutagenicity (chromosomal changes), teratogenicity or carcinogenicity, ie the appearance of malignant tumors of the skin.
Judging by the reviews about azathioprine, short-lived when the drug is administered any of side effects are usually held immediately after the abolition.
Azathioprine is contraindicated in pregnancy.In the treatment of this drug to women of childbearing age should use reliable methods of contraception.In cases where treatment is needed to azathioprine during lactation, breast-feeding is stopped.
also one of the contraindications to the use of the drug is an individual hypersensitivity to azathioprine or to its composition of mercaptopurine.
medicament for the treatment can not be applied in cases of renal insufficiency or inhibition of hematopoiesis, in particular, aplastic anemia and aplastic, lymphopenia, leukopenia, thrombocytopenia.Children's age is also a contraindication to the use of azathioprine.
Product description posted on this page is a supplement and a simplified version of the official version of the annotations to the drug.The information is provided for informational purposes only and is not a guide to self-medication.Before using the product you should consult with a specialist and to get acquainted with the instructions approved by the manufacturer.
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