Autoimmune hemolytic anemia - Treatment


1. The causes of autoimmune hemolytic anemia

2. Symptoms

3. treatment of autoimmune hemolytic anemia

Autoimmune hemolytic anemia - a disease in which the immunesystem destroys red blood cells, mistaking them for foreign substances.Lack of blood circulation is not the best way affects the operation of all systems and organs, so the effects of this process can be very serious and dangerous.The situation is aggravated by the fact that autoimmune anemia is treated quite difficult.

The causes of autoimmune hemolytic anemia

Like any other disease, autoimmune anemia is a result of a malfunction of the immune system.Its cause may be damage to the DNA sequence or gene mutation.Also autoimmune anemia is inherited, because DNA carries the information that is necessary for the human body.

distinguish idiopathic and symptomatic autoimmune anemia.Symptomatic arise against diseases that are accompanied by disturbances in the immunocompetent system.Most often, they are observed in Hodg

kin disease, systemic lupus erythematosus, chronic lymphocytic leukemia, rheumatoid arthritis, acute leukemia, chronic hepatitis and cirrhosis of the liver.

If the appearance of autoantibodies does not bind to some pathological process, it is necessary to speak of idiopathic anemia, which is about half of all autoimmune anemias.Autoantibodies are produced due to violations in the system of immune cells that perceive erythrocyte antigen as a stranger and begin to produce antibodies thereto.As a result, red cells undergo agglutination and further disintegration.Primarily hemolysis occurs in the liver, spleen, bone marrow.

In principle serological autoimmune hemolytic anemia are divided into five forms:

  • anemia with thermal hemolysin;
  • anemia with incomplete heat agglutinins;
  • anemia with biphasic hemolysin;
  • anemia with full cold agglutinins;
  • anemia agglutinins against normoblasts bone marrow.

Every form of anemia, there are some particular symptoms, serological diagnosis and course.The most common form of the second, which is 70-80% of all autoimmune anemias.


In the clinical picture are the two forms of the disease: acute and chronic.The first form occurs in patients with sudden severe weakness, fever, shortness of breath, palpitations, jaundice.In the second form, shortness of breath, fatigue and palpitations may be absent or mild.Revealed an enlarged spleen, and sometimes - liver.When autoimmune hemolytic anemia associated with cold antibodies, there is poor tolerance of cold and the development of the cold of the following symptoms: Raynaud's syndrome, urticaria, and hemoglobinuria.

treatment of autoimmune hemolytic anemia

the treatment of autoimmune hemolytic anemia preferred glucocorticoid hormones, almost always stop or reduce hemolysis.The most important condition of this therapy is the correct dosage and duration.In acute forms of prednisone in large doses (60-80 mg per day and 1 mg per kg of body weight).After remission dose is gradually reduced.The maintenance dose - 5-10 mg per day.Treatment of autoimmune hemolytic anemia lasts 2-3 months before the disappearance of hemolysis and negativation Coombs test.

some patients have the effect of immunosuppressants (azathioprine, 6-mercaptopurine, chlorambucil) and antimalarials (rezohin, delagil).The first have a particularly pronounced effect in autoimmune anemia associated with cold agglutinins.The dose of azathioprine and 6-mercaptopurine is 100-150 mg per day, and chlorambucil - 10-15 mg.When relapses and absence of a positive effect from the use of immunosuppressants and corticosteroids shows splenectomy.Blood transfusion in this disease should be carried out only for health reasons (eg when soporous state).It is recommended to select those donors whose red blood cells give negative Coombs.


This article is available exclusively in the educational purposes and is not research material or professional medical advice.

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