Obesity and Alzheimer's disease

mechanisms of obesity and Alzheimer's disease were linked.

People with type 2 diabetes are at risk of developing Alzheimer's disease.Moreover, people with a high level of insulin, long before they develop type 2 diabetes are also at risk of Alzheimer's disease.

more sugar enters the bloodstream, the more insulin your body has to produce.Over time, the pancreas produces insulin, exhausted and ceases to respond to the rise in blood glucose - developing insulin resistance and type 2 diabetes.

Insulin triggers the accumulation of amyloid

High insulin levels damage blood vessels.How to detect a group of researchers from the University of Washington led by Dr. Suzanne Craft, high insulin levels, and damage to the vessels of the brain leads to an increase in protein levels of beta-amyloid, the main component of senile plaques, are found in the brains of people with Alzheimer's disease.

Experiment

research team led by Kraft has selected 16 volunteers.Men and women between the ages of 55 to 81 docto

rs for two hours was injected into the blood glucose with insulin.This operation is allowed to maintain a normal blood sugar levels at very high urovvne insulin observed in people with insulin resistance.Then, the volunteers made a puncture of cerebrospinal fluid for further analysis.

It is a short increase in the level of insulin in the blood lead to results that Dr. Kraft called striking:

  • High levels of insulin triggers inflammation in the vessels of the brain.
  • Cerebrospinal fluid contains elevated levels of F2-isoprostane.In patients with Alzheimer's disease indicated extremely high levels of F2-isoprostane.
  • level of beta-amyloid in the brain increased.

Because overweight and sedentary lifestyles, as well as, possibly, because of the genetic risk factors for many people there is a high level of insulin.It has a bad effect on their heart, and on the work of the brain, confirms the findings of Dr. Samuel Kraft Gandhi, MD, Chairman of the Medical Scientific Advisory Board of the Alzheimer's Association and director of the Institute Faber neurology at Thomas Jefferson University (USA).

¬ęcontrol blood sugar levels and body weight - familiar to us things that have a positive impact not only on the health of the heart, but, as it turned out recently to help prevent Alzheimer's disease," - concludes Gandhi.

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