Hypophyseal syndrome : Causes, Symptoms and Treatment

If successful, the treatment prognosis adiposogenital dystrophy favorable, it is possible to stop the progression of the disease.

hypophyseal syndrome (Pehkrantsa-Babinski-Fröhlich syndrome) - a neuroendocrine disease characterized by metabolic disorders (obesity) and gonadal function (hypogonadism) as a result of the defeat of the hypothalamic-pituitary system.

Causes of adiposogenital dystrophy

  • pathologically proceeding pregnancy the mother (intoxication, toxoplasmosis and other infections);
  • bacterial and viral encephalitis and meningitis;
  • arachnoiditis;
  • brain tumors.

Manifestations adiposogenital dystrophy

Despite the fact that the disease occurs in childhood, it is most often detected in puberty, paying attention to the overweight child.

Disease equally susceptible to both boys and girls.It is noted distinctive body type: long limbs, disproportionately high growth, combined with the weakness of ligament-muscular system (flat feet, impaired posture, myopia, etc.), and abdominal obesi

ty, but intellectual development is usually not affected.

Boys may experience breast enlargement (gynaecomastia) and the small size of the external genitalia.It is often noted undescended testicle into the scrotum (cryptorchidism), and delayed sexual development (hypogonadism), including weak expression of secondary sexual characteristics (body hair pubic hair, armpits, may lack the mustache and beard), infertility.

Girls can be delayed or even complete absence of menstruation, and sexual organs are lagging behind in development, developing infertility.The skin is often dry and thin.

the internal organs found violations in the form of degenerative changes in the myocardium, the propensity to hypotension: gipomotornaya gallbladder dyskinesia, constipation, low blood pressure, etc.

Diagnostics hypophyseal syndrome

addition to a very characteristic symptoms and the appearance of the patients there is a decrease in hormone levels in the blood: testosterone, estrogen, lutropin, follitropin.

Spend genetic (chromosomal) study and examination to rule out other causes of hypophyseal syndrome (diabetes, thyroid, heart disease, etc. diseases).

To exclude neoplastic process, and other diseases of the brain and spend skull radiography sella MRI brain.Showing pelvic ultrasound and consultation related professionals.

Treatment adiposogenital dystrophy

If detected the primary cause of the disease, caused by disturbances in the hypothalamic-pituitary system, carry out the treatment of the underlying disease (if tumor lesion, it is carried out promptly and radiation therapy, chemotherapy).

also prescribed nootropics - drugs that improve the metabolic processes in the nervous system.

Held correction of weight (diet, exercise therapy, massage, physiotherapy, etc.).

the correction of hormonal status.As a rule, is engaged in endocrinology, together with the gynecologist, andrologist (urologist), therapist (clinical psychologist).With puberty substitution therapy is male or female sex hormones.

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