Rheumatoid arthritis (RPA) - a chronic, progressive autoimmune disease with a primary lesion of peripheral limb joints.Rheumatoid arthritis can occur at any age, but most often it occurs in women 18-50 years old.
- a chronic, progressive autoimmune disease with a primary lesion of peripheral limb joints.Rheumatoid arthritis can occur at any age, but most often it occurs in women 18-50 years old, if the arthritis occurs before 16 years - talk about juvenile (youth), arthritis, and if after 65 years - it is called the older arthritis (or senilearthritis)
One of the most important factors in causing rheumatoid arthritis (RPA) has a latent infection (staph, strep, virus, etc.).In 50% of patients the disease is preceded by acute respiratory infections, flu, sore throat
Now it is proved that there is a genetic predisposition to an autoimmune reaction of the body, attached to the genetic level, in one of the human chromosomes.When the life of a man of provoking factors (it is usually a viral or bacterial infection, hypothermia, the overall change in the immune background under the influence of stress, etc.) are activated protective immune responses and begins to produce antibodies (at RPA also called rheumatoid factor).
But in some cases the immune responses of the body are distorted and antibodies begin to act on their own tissue of the joints.This leads to inflammation and damage to them, that is developing the autoimmune process.Thus allocated biologically active substances and enzymes in the joint cavity.They fall into the intra-articular (synovial) fluid, here the same flock, and white blood cells, phagocytes.
As a result, there are small flat ulcerative defects on the surfaces of intra-articular cartilage.With the progression of cartilage disease destroyed more involving in the process of adjacent sections of bone to form in their small cystoid formations of three to five millimeters in diameter.
Over time, articular cartilage thinning, joint surfaces converge until closed, it will lead to further ankylosis - coalescing articular ends.Range of motion in the joint becomes less, and when no ankylosis, which leads to the patient's disability.In the first weeks of the disease in the inflammatory process involved and the small vessels of the joints, which is marked congestion and even mikrotrombozy, causing swelling, pain, feeling of heat around the joint.
most frequently (90%) found a slow and inconspicuous onset of the disease, and only 10% of rheumatoid arthritis begins acutely, with a high temperature, severe pain, swelling and redness of the skin overjoints.But the forecast of the disease in a timely intensive treatment is more favorable.
The disease often undulating - with exacerbation and remission process.With the progression of the inflammatory process occurs osteoporosis - decreased bone density in parts of the joint bones, and later their deformation occurs.It is noted swelling of the joints, which is associated with the appearance of the inflammatory response in the synovium, the lining inside the joint cavity, as well as increased production of synovial fluid (synovitis).
joint fluid begins to accumulate in the periarticular bags, between the folds and protrusions of the synovial membrane - this is often manifested in the form of bursitis in the area of the popliteal fossa this type of bursitis is called a Baker's cyst.This further limits the mobility of patients, as the pain of them is already ongoing.When inactivity increased osteoporosis, leading to increased bone fragility.
positive influence on the course of the disease the patient has the ability to actively resist the disease, his mental attitude, the desire to recover and meticulousness in carrying out medical procedures.Therefore, a periodic medical control the progress of the disease, the timely diagnosis of an inflammatory process, particularly during exacerbations, appropriate treatment and effective prevention.
Gradually, when systematically conducted by treatment of the inflammatory process activity in the arthritis decreases, but emerging changes remain, and we must try, so they did not progress, so you should make active use of the best methods of treatment, and to prevent relapse and the emergence of strainswithout tightening with treatment in hospital (clinic).
Abdominal pain syndrome in children is one of many diseases of the gastrointestinal tract. Pain in abdominal pain in children is a s...
Currently, there is a huge selection of bracket systems, which are constantly being improved, but the classics of orthodontics remain time-tes...
DNA diagnosis of Gilbert's syndrome will help those who want to know a detailed picture of genetic abnormalities. It is possible to ...