Arthritis in tsitosteato necrosis

As disease of the pancreas leads to joint damage.

Tsitosteatonekroz - is widespread destructive (necrotic) loss of adipose tissue that occurs on a background of severe lesions of the pancreas (pancreatitis, cancer and others) with the release of pancreatic enzymes in the blood (amylase, trypsin, lipase, chymotrypsin).

In the subcutaneous fat and other tissues appear foci of necrosis and joint expressed phenomena of arthrosis.The disease is more common in men over 40-50 years.

defeat of joints in systemic tsitosteatonekroze

To the development of arthritis with severe disease is:

  • immediate impact of enzymes on tissue synovial membranes of the joints and destruction (necrosis) adjacent adipose tissue.
  • Necrosis of adipose tissue in the bone marrow epiphysis mating articular ends leads to the formation of pockets of melting them with the formation of aseptic (non-infected) fistula.
  • enter the blood enzymes are not only necrosis of the adipose tissue, but also damage to the vessel walls.They also o
    bserved microembolisms fat and arterial thrombosis, caused by violation of blood clotting, which in turn can lead to necrosis of the bone.

main clinical manifestations of arthritis when tsitosteatonekroze

the skin and the joints, usually develops in the background of severe general condition characteristic of diseases of the pancreas in the acute phase: the expression of pain, fever, poliserozita (pleurisy, ascites)paranephritis, thrombophlebitis, etc.

One of the most typical signs tsitosteatonekroza is the presence of cutaneous and subcutaneous nodules, nodules resembling with erythema nodosum, but they may have different dimensions, dense texture, painful on palpation, and the skin over them hot and red.Most often, they are located in the ankle joints, the front of the leg, on the face, trunk.Sometimes these sites are opened with the release of fat-like content, but may dissolve on their own with the formation of rough scars or pigmentation areas.

More than half of all cases of joint damage when tsitosteatonekroze is severe and is accompanied by severe pain, swelling and the appearance of the presence of effusion in the joint cavity.It often affects the joints of the feet and the small joints of the hands, but the hip and shoulder joints, as a rule, do not inflame.In addition, there is an inflammation of the sacroiliac, sternoclavicular, and temporomandibular joints.

Over time, with the progression of the underlying disease of the joints increases with periostitis inflammation (inflammatory reaction of the periosteum) and necrosis of fat tissue in the area of ​​the mating epiphyseal bone.This leads to the formation of small intraosseous cyst with MS around the area and even the appearance of sinus tracts.

Tsitosteatonekroz during intensive therapy can occur in waves.At the same time during remission possible subsidence of the symptoms of arthritis, as well as the disappearance of the nodules in the skin and subcutaneous fat.But in general, the disease may continue for several years and is recurrent in nature.Sometimes possible death due to the underlying disease (pancreatic cancer, acute pancreatitis and the like).

Diagnosis of arthritis when tsitosteatonekroze

In addition to the research conducted on the basic disease (lesions of the pancreas), is carried out:

  • ultrasound and X-ray examination of joints, CT or MRI (presence of specific cystoid restructuring necrosis areas, tissue changessurrounding the joint, the presence of joint effusion and periarticular bags);
  • study of synovial fluid from the joints of patients (absence of pathological microflora, but the presence of elements of the cell debris, enzymes, cholesterol crystals).

Arthritis Treatment tsitosteatonekroze

treatment of pancreatitis in many cases reduces the manifestations of arthritis, but in some cases this can be achieved only surgical treatment of the underlying disease.

to relieve arthritis symptoms prescribe painkillers and non-steroidal anti-inflammatory drugs, corticosteroids, and also conduct local therapy, prescribed drugs polyenzyme, relieve toxicity.

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