immunodeficiency states

What is the immune system and immunodeficiency.

word "immunity" for a long time came into use not only doctors, but also non-medical people: we often hear it in various commercials, on the protection of the environment programs, etc.

Indeed, dynamic changes of parameters of the immune system occurs in response to various conditions of the body: infection, trauma, tumors.Is this pathology?In most cases - no, this is a normal reaction of a living organism.After all, the main function of the immune system - it is a struggle with all the alien, whether a bacterium or a tumor cell.

However, in some cases, changes in the immune system are long-term, pathological character, such conditions are called immunodeficiency (CID).Depending on the causes, they are divided into primary and secondary.

secondary IDS are the result of serious external effects on the body: radiation, immunosuppressive chemotherapy, severe infections (eg, HIV).As compared with the first group, they are far more common, however, are typi

cally less diagnostic problems as a consequence are already known factors.In contrast, primary immunodeficiency characterized by severe underdiagnosed.Often, patients with primary CID do not reach an adequate diagnosis.In this regard, in this issue have focused on is primary immunodeficiency disorders.

In addition, symptoms and treatment of secondary IDS tactics are very similar to those of the primary IDS.In most cases, as in the main primary and in secondary immunodeficiencies it is infectious syndrome.However, it is important to remember that a violation of the basic functions of the immune system - recognition of his and others' - leading to an increased frequency of autoimmune, cancer and rare - allergic diseases in patients with IDS.In addition, immunity defects may be accompanied by inflammation and excessive control lymphoproliferation disorder.Some particular aspects of immunodeficiency states devoted several articles in this issue.

Primary immunodeficiency (PIDS) are a group of severe genetically determined diseases caused by a violation of one or more immune mechanisms of protection.Most of these states will debut in early childhood increased tendency to infectious diseases.

Currently, described over a hundred forms of PIDS.The incidence of primary immunodeficiencies an average of 1: 10,000.Early diagnosis and adequate therapy PIDS can achieve a stable general condition of patients in most of these diseases.However, due to low vigilance pediatricians and general practitioners in relation to primary immunodeficiency observed unreasonably high disability and mortality in patients with PIDS, caused by infectious and other complications.

Magazine "Difficult patient» №2-2007.

article is provided by a charitable foundation to help children with impaired immunity "Sunflower".

spelling and syntax of the source maintained at a reprint.

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