Primary immunodeficiency : common variable immunodeficiency

Common Variable Immune Deficiency - a disorder characterized by low levels of immunoglobulins (antibodies) in the blood serum, and increased susceptibility to infections.

In most cases, the genetic causes of the low levels of serum immunoglobulins are not known.This form of immunodeficiency occurs relatively frequently, and therefore in its title has the word "common".The degree and type of failure of immunoglobulins in the blood serum, as well as the clinical course differ from patient to patient, hence, the word "variable."

In some patients there is a decrease of both IgG and IgA.Other levels of all three major types of immunoglobulins can be reduced (IgG, IgA and IgM).

Clinical signs and symptoms may also have varying degrees of severity - from mild to severe.Frequent and unusual infections may occur first during early childhood, adolescence or adults.In most patients, this condition is diagnosed only at the age of 20-40 years.However, approximately 20% of patients the symptoms appear or immunodef

iciency condition is detected before the age of 16.

Due to the relatively late onset of symptoms and diagnosis "COMMON VARIABLE IMMUNODEFICIENCY 'disease also has other names, including acquired agammaglobulinemia, agammaglobulinemia adult or late
hypogammaglobulinemia.

term "acquired immunodeficiency" is now used to refer to a syndrome caused by the AIDS virus (HIV), and should not be used to designate the common variable immune deficiency (CVID) due to a significant difference between these disorders.

Causes of CVID are largely unknown, but recent studies have implicated a small group of genes in some patients.In recent decades, the study of cells of the immune system in patients with CVID have revealed many violations of lymphocytes.

Most patients revealed normal numbers of B-lymphocytes, in which there is no normal
maturation to plasma cells capable of producing different types of immunoglobulins and antibodies.In other patients, the function of T helper lymphocytes not sufficient for normal antibody production.A third group of patients have excessive numbers of cytotoxic T lymphocytes, although the role of these cells is not clear in this disease.

Article courtesy of a worldwide organization IPOPI, working to improve the lives of people with primary immunodeficiency.
Copyright 2007 owned fund Immune Deficiency Foundation, USA."Guidelines for the primary immunodeficiency diseases for patients and their families", from which the material is taken under the license, was developed Immune Deficiency Foundation with support from Baxter Healthcare Corporation.

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