Common Variable Immunodeficiency (CVID) can be both men and women.In some patients, symptoms occur in the first years of life, however, many patients may only occur at the age of 10-30 years or even later.
main manifestation in most patients with CVID are recurrent infections of the ear, sinuses, nose, bronchi and lungs.At considerable severity and the frequency of lung infections may be irreversible defeat of the bronchi (airways) to the development of chronic changes - expansion and scarring - these structures.This condition is called bronchiectasis.
These infections are usually caused by bacteria, is widely-nennymi the propagation among the people and often cause pneumonia (Haemophilus influenzae, pneumococci, and staphylococci).Treatment of pulmonary infections aimed at preventing their recurrence and the accompanying chronic damage to lung tissue.Regular cough in the morning that produces yellow or green sputum may be a manifestation of chronic infection or bronchiectasis
In CVID can be increased cervical, thoracic or abdominal lymph nodes.The exact cause is unknown, but an increase in the lymph nodes can be caused by infection, immune regulation violation or a combination of these factors.Similarly, there is often an increase in the spleen, and increased nodular lymphocyte accumulation in the intestinal walls, known as Peyer's patches.
Despite the fact that in patients with CVID reduced antibody and blood levels are low immunoglobulins (hypogammaglobulinemia), some antibodies produced by the body of patients, can attack their own tissues (autoantibodies).These autoantibodies may attack and destroy blood cells (eg, red blood cells, white blood cells or platelets).Although most patients with CVID is the first manifestation of recurrent bacterial infection, approximately 20% of immune deficiency is detected for the first time as a significant reduction in the number of platelets in the blood or even severe anemia due to destruction of red blood cells.
autoantibodies may also cause arthritis or endocrine disorders, such as thyroid disease.Some patients with CVID who are not receiving adequate immunoglobulin replacement therapy may also develop a painful inflammation of one or more joints.This condition is called polyarthritis.
In most such cases, the joint fluid does not contain bacteria.To ensure that no treatable infection in the joints, can be a needle to take a sample of synovial fluid and examine it for the presence of bacteria.
In some cases, are difficult to diagnose the cause of this condition may be bacteria of the genus Mycoplasma.Typically, arthritis associated with CVID may involve the larger joints such as knees, ankles, elbows and joints of hands.The smaller joints (eg finger joints) are rarely affected.
Symptoms of joint inflammation usually disappear with adequate immunoglobulin therapy and appropriate antibiotics.However, in some patients, arthritis may occur even if the sufficient immunoglobulin replacement therapy.
Some patients with CVID there are complaints on the gastro-intestinal disorders, such as abdominal pain, flatulence, nausea, diarrhea and decreased body weight.Careful evaluation of the digestive organs may reveal a violation of fat intake and certain sugars.If you take a small sample (biopsy) of the intestinal mucosa, can detect the characteristic changes.These changes help to diagnose and treat this disorder.
Some patients with impaired function of the digestive tract in biopsies and stool analysis revealed a microscopic parasite - Giardia Giardia.The destruction of the parasite by means of drugs can eliminate gastrointestinal disorders.
Finally, patients with CVID may increase the risk of cancer, especially cancer of the lymphoid system, skin and gastrointestinal tract.In the absence of complications of CVID is not accompanied by physical disabilities.Some patients with CVID are enlarged spleen and lymph nodes.
With the development of chronic lung disease in a patient may decrease physical performance and vital lung capacity (the maximum amount of air that can be taken into the lungs).Gastrointestinal tract in some cases can affect the normal growth of children or lead to weight loss in adults.
Article courtesy of a worldwide organization IPOPI, working to improve the lives of people with primary immunodeficiency.
Copyright 2007 owned fund Immune Deficiency Foundation, USA."Guidelines for the primary immunodeficiency diseases for patients and their families", from which the material is taken under the license, was developed Immune Deficiency Foundation with support from Baxter Healthcare Corporation.
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