tumor is usually localized in the pancreas, but in rare cases the development of tumor cells enterohromafinnyh gastrointestinal tract or clusters of ectopic pancreas tissue in the stomach or intestinal wall.
hypoglycemic episodes occur sporadically because insulin secretion is periodic.
disease is characterized by an early manifestation of symptoms, so diagnosis can be made at an early stage of the disease, when the tumor is small in size.
However rarity of the disease and low awareness of her doctors often lead to erroneous conclusions.
Symptoms Clinical manifestations of Whipple's triad are called insulinomas and includes the following symptoms:
attack of hypoglycemia may manifest the following symptoms:
Diagnosis is based on anamnesis, examination results (including neurological examination) and registered a decline of plasma glucose in those cases where it is proved that the secretion of insulin with enhanced or not inhibitedand excluded other causes of hypoglycemia (use of hypoglycemic agents, diseases of the hypothalamic-pituitary system, adrenal lesions, hepatic failure, some other tumors).
To do this, carry out a test with fasting, investigate the secretion of proinsulin, C-peptide, cortisol.For the differential diagnosis and clarify the features may require instrumental examination (ultrasound, CT angiography).
Treatment is aimed at the normalization of plasma glucose levels.Possible subsequent surgery to remove the tumor.Patients with metastatic or ineffective surgical treatment is prescribed chemotherapy.
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