Pheochromocytoma : what it is

Pheochromocytoma : what it is
In the body, there may be a variety of tumors, including actively producing hormones and significantly affect the livelihoods of the whole organism.Such tumors can be attributed pheochromocytoma.This hormonally active tumor that occurs in the zone of the adrenal medulla and produces large amounts of catecholamines, which include adrenaline, noradrenaline, and their analogues.


pheochromocytoma Pheochromocytoma - a tumor of the adrenal glands, producing hormones.In rare cases, pheochromocytoma similar structures can be found outside the adrenal zone, then they typically occur in the area of ‚Äč‚Äčnodes sympathetic part of the autonomic nervous system.Pheochromocytoma detected while in the abdominal or thoracic cavity in the pelvic area, blood vessels of the head or neck.

This tumor is considered to be quite rare, on average, it occurs in two or three cases per 100 thousand. People, adults get sick more often women, children usually suffer the boys.

Approximately 25% of the ill scientists traced a g

enetic predisposition to pheochromocytoma or may be identified various other tumors in the endocrine system.

role of hormones in the development of tumor

When pheochromocytoma basis of disease constitute intensively producing hormones - catecholamines, epinephrine and norepinephrine.These hormones - a normal substance of the body, they are constantly produced by the body for its own needs.

In any conditions of stress, physical or emotional, their number increases dramatically.Through them there is the need to restructure the body under stressful conditions - activation of metabolism, increased heart rate, blood redistribution and fever.

In addition, the adrenaline released when fear violent agitation, active physical exercise that can increase blood pressure and increase blood flow to the muscles, to actively break down carbohydrates and fats.

This generally improves stamina, allowing under stress and fear to run away or defend themselves.

Norepinephrine complements the action of adrenaline, a hormone being "against the enemy."In his isolation increases muscle strength, increased levels of aggression.If the level of these hormones will be greatly increased - the body is bad.This occurs when a pheochromocytoma.

manifestations of pheochromocytoma

With the development of its active pheochromocytoma cells produce hormones to increase the amount, with the main symptoms of the tumor - is a manifestation of the action of hormones released.

Usually there is a persistent increase in blood pressure with constant crisis course, developing orthostatic hypotension with syncope with a sharp rising from bed, lose weight, change the body's sensitivity to glucose.complications of high blood pressure may occur in the form of strokes and heart attacks, heart failure, left ventricular damage brain.

a typical crises in pheochromocytoma constantly elevated blood pressure with episodes of hypertension attacks, a sharp increase in the pressure to the critical numbers.

When crises hypertension accompanied by signs of excess hormones - sweating, pale skin, profuse urination, trembling muscles, problems with heart rhythm in the form of sharp tachycardia arrhythmia, high blood glucose levels.Perhaps the development of seizures, severe headaches, severe anxiety, fear of death and panic.

How to detect pheochromocytoma

reveal sharply elevated levels of adrenaline and noradrenaline in the blood is not easy, these substances have a short life span in the blood, they disintegrate in a few minutes from the moment of their blood.

Increased secretion of catecholamine can be determined by the level of exchange of substances into the blood serum or products are stable enough, and to determine their already easier.

Number of epinephrine and norepinephrine metabolites after an attack of hypertension is increased during the day.

Commonly used definition of substances such as Metanephrine and Normetanephrine, excretion vanillylmandelic acid.

To improve analysis and incorrect results exclude the accuracy prescribed a special diet for five days to analyze and eliminate the use of certain medications - antidepressants, reserpine, clonidine, paracetamol and dipyrone.

At higher levels of catecholamines and their metabolites in blood and urine need to spend more than aiming to diagnose and find the tumor using ultrasound initially, and then to a computer or magnetic resonance imaging.In order to determine whether in the adrenal tumor is localized or she vnenadpochechnaya, scintigraphy is performed with certain substances.

How to treat pheochromocytoma

The basis of treatment of pheochromocytoma is surgical removal of the tumor, but before surgery apply certain medicines to prepare the patient for surgery.

This training should take no less than six weeks to adequately restore the water-salt metabolism of the body and compensate for the volume of circulating blood.Alpha-blockers are usually used.

In operation, to avoid pressure jumps, are antihypertensive drugs are required, as anesthesia may be a stress factor and result in the release of hormones in the blood.

should also remember that after surgery hypotension may occur because the body is used to the high doses of hormones, and the need to introduce additional fluid to maintain pressure.

In rare cases, if you can not carry out the operation conservative therapy of pheochromocytoma methyl tyrosine.However, the drug has many side effects.

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