The alleged causes of psoriasis are many, but the true mechanisms that give start illness, never fully disclosed.This explains the difficulty of finding therapeutic approaches to these patients and the relevance of studying the etiology of the disease.
only thing dermatologists today are convinced of is that parasites, infections and viruses as causes of psoriasis can completely reject - these theories have not found conclusive evidence in any of the studies.
In 1960-70 there was the theory of "nervous" origin of psoriasis, confirmed by many facts.It was found a link manifestation of the disease and trauma.The results of subsequent neurological studies have shown that patients with psoriasis are really significant functional disorders of the central and peripheral nervous system.This fact does not prove, but gave some reason to believe the dominant cause of psoriasis neur
many domestic and foreign researchers have identified violations of the liver, pancreas, and various kinds of exchange (nitrogen, water and salt, carbohydrate, protein, lipid, etc.) In patients with psoriasis.This theory is confirmed by the results of a dietary approach in the treatment of dermatoses: a low-calorie diet and moderate fasting improves skin condition and can be an effective complement to the main course of treatment.
known fact that about a quarter of patients with psoriasis history burdened with diabetes and impaired glucose metabolism.However, experts attribute this to the secondary features, caused by psoriasis.
Perhaps these pathological processes play a role in the development of the disease, but most likely will not start.
According to the results of the research, the etiology and pathogenesis of psoriasis has a close relationship with endocrine disorders, such as thyroid and adrenal glands.In chronically ill psoriasis was decreased or increased thyroid function, as well as reducing the glucocorticoid function of the adrenal cortex.
patients with psoriasis often reveals:
drugs, lowering the secretion of growth hormone and insulin, often have a positive effect on psoriasis, suggesting a possible role of endocrine and metabolic abnormalities in the appearance of psoriasis.The same can be said of the sex hormones, such as testosterone and estrogen, as well as prolactin and progesterone.Support for this theory is the fact that often during pregnancy improves psoriasis (time until complete remission), and possible relapse after birth.
Despite the presence of many theories of psoriasis, of predisposing genetic factors shall prevail.Back in the 1970s, in the vessels of the skin of patients with psoriasis and their blood relatives of the same type have been discovered ultrastructural lesions that appear long before the disease.The risk of inheritance of psoriasis in the presence of the disease in one of the parents is 8% (according to some sources - 15%), both parents - 41%.Pockets of infection (chronic tonsillitis, etc.), Contributing to the emergence of severe immune disorders may be a precipitating factor in realizing a genetic predisposition.
Already later as a result of genome analysis have been allocated a place of localization of specific genes on the genetic map of chromosome associated with the development of psoriasis.Psoriasis patients also have been identified and some of the other genes involved in the development of other autoimmune diseases, suggesting that autoimmune nature of psoriasis.
In the 1980s it was found that cellular immunity disorders are the leading mechanism in the development of psoriasis.The leading role of autoimmunity confirmed autoantibodies in serum and antigenic components found in psoriatic scales extracts and absent in healthy skin.These data indicate psoriasis as a systemic disease in which the pathogenesis an important role is played by immunological disorders.However, it should be understood that the immune responses are played in the whole organism, so you need to take into account the totality of all the factors predisposing to the disease.
assumption was made in the mid-1990s that psoriasis can be triggered superantigens - products of bacteria and viruses have a protein nature.Superantigens are able to elicit an immune response in the body due to antigen-recognition receptors, resulting in an excessive amount released cytotoxins - antibodies with cell poisons character.In other words, psoriasis is an allergic reaction of tissues on viruses and microorganisms streptococcus products.
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