Leukemia : causes of development and types

Leukemias are characterized by uncontrolled growth of immature (blast) forms of white blood cells in the bone marrow, suppression of normal hematopoiesis processes it and distributing defective blood flow throughout the body cells with the subsequent formation in tissues and organs lesions such tumors.

At the heart of the development of leukemia may lie a variety of factors, often a combination thereof, and the conditions that trigger the appearance of the disease.

Here are the basics of their group:

  • infectious virus (retroviruses, the Epstein - Barr virus, and others.);
  • hereditary, genetically fixed disease associated with defects in chromosomes, mutations (these include syndromes such as Turner's syndrome, Down syndrome, Blum et al.);
  • toxic effects on bone marrow medications (cytotoxic agents, antibiotics, etc.), Domestic agents (detergents, dyes, preservatives, etc.), industrial toxins (insecticides and defoliants, creosote, benzene, tar, toluene, organicsolvents, paints and varnishes, etc.);
  • influence of ionizing radiation (X-ray, ultraviolet, gamma rays, and others.).

All these factors damage the immature (blast) and still insufficiently differentiated bone marrow cells appear different mutations, some of which later inherited and transmitted even from generation to generation.

main forms of leukemia

Depending on what stage of maturation of white blood cells fails, isolated acute leukemia in which the development of white blood cells ceases to undifferentiated blast forms of level occurring more malignant and short-term and chronic leukemias, which are characterized by the presence of largeamount with respect to differentiated forms of leukocytes.This form of leukemia, a benign, and with appropriate treatment patients live long enough.

there are many varieties (depending on the type of cell forms leukocytes) in the two groups of leukemia, which affects the characteristics of their clinical manifestations and course of the disease, as well as the selection of the optimal treatment.Nevertheless, for all types of leukemia characterized by common symptoms, certain patterns of development, outcome.

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